软肝散结散方治疗由HBV引起的肝硬化临床疗效观察  

Curative Observation of Using Ruangan Sanjie Powder to Treat Cirrhosis Caused by HBV

作　　者：卢全立 

机构地区：[1]周口市中医院,河南周口466000

出　　处：《四川中医》2015年第7期59-61,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的：分析软肝散结散方治疗由乙肝病毒引起肝硬化的临床效果。方法：选取我科2012年6月-2014年6月乙肝后肝硬化代偿期患者共156例,随机分为实验组和对照组。实验组予以阿德福韦酯联合软肝散结散方治疗,对照组单用阿德福韦酯。对比两组患者治疗前和治疗3个月后的肝功能、肝纤维化指标、B超指标和HBV-DNA阳性率。结果：两组患者治疗后的谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TBIL）较治疗前显著降低,白蛋白（ALB）较治疗前显著升高（P〈0.05）;实验组治疗后的ALT、AST、TBIL较对照组显著降低,ALB较对照组显著升高（P〈0.05）。两组患者治疗后的透明质酸（HA）、层粘连蛋白（LN）、III型前胶原（PC-III）和IV型胶原（VI-C）较治疗前显著降低（P〈0.05）;实验组治疗后的HA、LN、PC-III和IV-C较对照组显著降低（P〈0.05）。治疗后两组患者的HBV-DNA阳性率较治疗前显著降低（P〈0.01）;治疗后实验组的HBV-DNA阳性率较对照组显著降低（χ2=5.7943,P=0.0161〈0.05）。治疗后两组患者的脾脏厚度、门静脉主干直径和脾静脉内径较治疗前显著降低（P〈0.05）;治疗后实验组的脾脏厚度、门静脉主干直径和脾静脉内径较对照组显著降低（P〈0.05）。结论：软肝散结散方联合抗乙肝病毒治疗乙肝后肝硬化可改善其肝功能、肝脏纤维化和脾功能亢进程度,具有较好的临床疗效。Objective： To analyze the clinical effects of Ruangan Sanjie Powder for liver cirrhosis caused by hepatitis B virus. Methods： 156 cases of patients with liver cirrhosis caused by hepatitis B virus in our department after June 2012 to June2014were randomly divided into experimental and controlled groups. The experimental group received adefovir combined with Ruangan Sanjie Powder and the controlled group was treated with adefovir. The liver function,liver fibrosis,B- index and HBV-DNA positive rate before and three months after treatment in two groups of patients were compared. Results： The alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST） and total bilirubin（ TBIL） in two groups of patients after treatment were significantly lower than before treatment,albumin（ ALB） was significantly higher than that before treatment,P 〈0. 05. ALT,AST,TBIL in the experimental group after treatment were significantly lower than the controlled group,ALB was significantly higher than the controlled group,P 〈0. 05. The hyaluronic acid（ HA）,laminin（ LN）,III procollagen（ PC- III） and type IV collagen（ VI- C） in two groups of patients after treatment was significantly lower than before treatment,P 〈0. 05. The hyaluronic acid（ HA）,laminin（ LN）,III procollagen（ PC- III） and type IV collagen（ VI- C） in the experimental group after treatment was significantly lower than the controlled group,P 〈0. 05. After treatment,HBV- DNA positive rate of the two groups were significantly lower than before treatment,P 〈0. 01; positive rate of HBV- DNA after treatment,the experimental group was significantly lower than the controlled group,χ2= 5. 7943,P = 0. 0161 0. 05. The spleen thickness,before the main portal vein diameter and splenic vein diameter in two groups of patients after treatment were significantly decreased than before treatment,P 〈0. 05. The spleen thickness,before the main portal vein diameter and splenic vein diameter in experimental group were significantly

关 键 词：软肝散结散方 乙肝病毒 肝硬化 

分 类 号：R575[医药卫生—消化系统]