极光激酶Ap53及p21WAF1协同表达在非小细胞肺癌预后中的价值  

Prognostic value of combined expression of Aurora A, p53 and p21 WAF1 in patients after curative resection of non-small cell lung cancer

作　　者：李雪[1] 刘宁波[1] 任鹏[2] 曹勤琛 王鹏[1] 赵路军[1] 陆波 王平[1] 

机构地区：[1]天津医科大学肿瘤医院放疗科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室,300060 [2]天津医科大学肿瘤医院放疗科国家肿瘤临床医学研究中心食管外科,300060 [3]美国托马斯杰弗逊大学医学放疗科

出　　处：《中华肿瘤杂志》2015年第7期512-516,共5页Chinese Journal of Oncology

基　　金：国家自然科学基金（81372518）;天津市应用基础及前沿技术研究计划（12JCQNJC06600）

摘　　要：目的探讨极光激酶（AuroraA）、Ki-67、p53和p21WAF1在行根治术非小细胞肺癌（NSCLC）患者预后中的价值。方法采用免疫组化检测AuroraA、Ki-67、p53和p21WAF1在58例NSCLC根治术后患者中的表达情况，分析各指标的表达与患者临床病理特征及预后的关系。结果AuroraA、Ki-67、p53和p21WAF1在NSCLC中的阳性率分别为89．7％（52／58）、53．4％（31／58）、46．6％（27／58）和34．5％（20／58）。AuroraA高表达患者的淋巴结转移率为69．2％，高于低表达者（37．8％，P=0．045）。AuroraA低表达组和高表达组患者的3年生存率分别为75．0％和46．0％，差异有统计学意义（P=0．039）。AuroraA高表达和p53阳性组、AuroraA高表达或p53阳性组、AuroraA低表达和p53阴性组患者的3年生存率分别为40．0％、65．0％和82．1％，差异有统计学意义（P=0．039）。Cox多因素分析结果显示，AuroraA和p53联合检测为影响NsCLC患者预后的独立因素（P=0．015）。结论AuroraA和p53为影响NSCLC患者预后的不良因素，与p53突变相关的AuroraA高表达为影响NSCLC患者预后的独立不良因素。Objective The aim of this study was to investigate the prognostic value of combined expression of Aurora A, Ki-67, p53 and p21 WAF1 in patients after curative resection of non-small cell lung cancer（NSCLC）. Methods Expressions of Aurora A, Ki-67, p53 and p21 WAF1 in 58 tumor samples from resected primary NSCLCs were detected by immunohistochemistry. The correlation of proteins, survival and clinicopathological characteristics was analyzed. Results The positive rates of Aurora A, Ki-67, p53 and p21 WAF1 expression were 89.7% （52/58）, 53.4% （31/58）, 46.6% （27/58） and 34.5% （20/58）, respectively. Aurora A expression was positively correlated with nodal metastasis （69.2% vs. 37.8% , P = 0.045）. The univariable analysis showed that the overall survival （OS） was 75.0% in patients with low Aurora A expression and 46.0% in patients with high Aurora A expression （P= 0.039）. The 3-year survival rate was 40.0% in patients with positive expression of Aurora A and p53, 65.0% in the patients with positive expression of Aurora A or p53, and 82.1% in the patients with negative expression of Aurora A and p53 （P=0. 039 ）. The Cox regression model showed that combined expression of Aurora and p53 is an independent factor affecting the prognosis of NSCLC patients （P = 0.015）. Conclusions Our findings suggest that the positive expression of Aurora A, Ki-67 and p53 proteins is an unfavorable factor affecting the prognosis for NSCLC patients, and the overexpression of Aurora A is an independent unfavorable factor association with shorter OS in NSCLC patients. Detection of positive Aurora A and p53 expression may be a useful predictive prognostic indicator for NSCLC patients.

关 键 词：癌 非小细胞肺 预后 免疫组织化学 AURORA A Ki-67 p53 P21 WAF1 

分 类 号：R734.2[医药卫生—肿瘤]