女性功能性消化不良患者血清褪黑素和雌激素水平的变化  

Changes in serum melatonin and estrogen levels in women with functional dyspepsia

作　　者：朱梦霞[1,2] 黄群[3] 王芳[1] 谢娟[4] 向琼[5] 张琍[2] 

机构地区：[1]南华大学外科学总论教研室,湖南省衡阳市421001 [2]南华大学附属第二医院消化内科,湖南省衡阳市421001 [3]怀化市第三人民医院消化内科,湖南省怀化市418000 [4]南华大学诊断学教研室,湖南省衡阳市421001 [5]南华大学临床技能实验中心,湖南省衡阳市421001

出　　处：《世界华人消化杂志》2015年第19期3038-3044,共7页World Chinese Journal of Digestology

基　　金：湖南省卫生厅基金资助项目;No.B2010-053;湖南省研究生科研创新基金资助项目;No.2011B383~~

摘　　要：目的:探讨女性功能性消化不良患者与血清褪黑素和雌激素水平的关系,初步探讨功能性消化不良发病机制,为寻找有效治疗功能性消化不良的临床方法及诊断功能性消化不良不同类型提供依据.方法:取符合RomanⅢ诊断标准的60例女性功能性消化不良患者为实验组,并分成两组:35例上腹痛综合征组(epigastric pain syndrome,EPS)、25例餐后不适综合征组(postprandial distress syndrome,PDS);30例无功能性消化不良症状及无器质性疾病体检健康者作为对照组,分别测定血清褪黑素及雌激素水平.结果:(1)功能性消化不良组及PDS组血清褪黑素水平均较对照组明显升高(P<0.05);P D S组较E P S组也明显升高(P<0.0 5);而E P S组与对照组比较(P>0.05);(2)P D S组血清褪黑素水平症状重者较症状轻者升高(P<0.05);其中女性EPS组血清褪黑素水平症状重者较症状轻者减低(P<0.05);(3)功能性消化不良组(围绝经期)血清雌激素水平较对照组减低(P<0.05);(4)功能性消化不良组(围绝经期)血清雌激素水平症状重者较症状轻者减低(P<0.05);(5)功能性消化不良组(围绝经期)血清褪黑素水平与雌激素水平之间不存在相关性(r=-0.03,P>0.05).结论:(1)血清褪黑素水平的改变在功能性消化不良特别是PDS的发病中起作用,与EPS的发病无明显关系;(2)血清褪黑素水平可能对功能性消化不良临床类型分型的诊断有一定意义;(3)血清雌激素水平改变在围绝经期功能性消化不良发病中起作用,补充外源性雌激素可能改善围绝经期功能性消化不良患者的症状.AIM：To detect the levels of serum melatonin and estrogen in women with functional dyspepsia（FD）,and to evaluate the possible mechanism of FD.METHODS：Sixty women diagnosed with FD according to Roman Ⅲ criteria were included into an experimental group,which was further divided into two subgroups：patients with epigastric pain syndrome（EPS）（n = 35） and those with postprandial distress syndrome（PDS）（n = 25）.Thirty healthy person were chose as normal controls.Serum melatonin and estrogen levels were measured and analyzed in these subjects.RESULTS：In the FD group and PDS subgroup,the levels of serum melatonin were significantly higher than that in normal controls（P 0.05）.In the PDS subgroup,the concentration of serum melatonin was significantly higher than that in the EPS subgroup（P 0.05）.There was no significant difference in the concentration of serum melatonin between the EPS subgroup and the normal control group（P 0.05）.PDS patients with severe symptoms displayed a higher melatonin concentration as compared withpatients with moderate symptoms（P 0.05）.EPS patients with severe symptoms displayed a lower melatonin concentration as compared with patients with moderate symptoms（P 0.05）.In the FD subgroup（menopausal transition）,the concentration of serum estrogen was significantly lower than that in normal controls（P 0.05）.FD patients（menopausal transition） with severe symptoms displayed a lower estrogen concentration as compared with patients with moderate symptoms（P 0.05）.In FD patients（menopausal transition）,there was no significant correlation between the levels of serum melatonin and estrogen（r =-0.03,P 0.05）.CONCLUSION：The alteration of serum melatonin may play a role in the pathogenesis of FD,especially PDS,but has no obvious relation with EPS.Serum melatonin level maybe have certain significance for the diagnosis of various clinical forms of FD.The alteration of serum estrogen may play a role in the development of FD.Supplementing exogenou

关 键 词：功能性消化不良 褪黑素 雌激素 消化不良症状积分 

分 类 号：R57[医药卫生—消化系统]