药物性肝病的发病类型及保肝药物的作用机制  

Drug-induced liver disease:Types and mechanisms of action of liver-protecting drugs

作　　者：汤静[1] 朱玲[2] 胡珊珊[3] 刘皋林[1] 

机构地区：[1]上海交通大学附属第一人民医院临床药学科,上海市200080 [2]泸州医学院,四川省泸州市646000 [3]上海交通大学医学院附属瑞金医院药剂科,上海市200025

出　　处：《世界华人消化杂志》2015年第19期3045-3052,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;Nos.81100289;81470852;上海市科委生物医药领域科技支撑基金资助项目;No.13431900503;上海市卫生系统优秀青年人才培养基金资助项目;No.XYQ2013091;上海交通大学医工交叉面上基金资助项目;No.YG2012MS02~~

摘　　要：药物性肝病是临床常见的药物不良反应之一,急性肝损伤是药物性肝病最常见的发病形式,少数可发生威胁生命的肝衰竭.药物性肝病的确诊,需要排除其他原因,而患者常常合并使用多种药物,不易判断是何种药物所导致的肝病,且出现临床症状之后,缺乏规范化的治疗.本文将药物性肝病的病理类别与常见保肝药物的作用机制作一综述.Drug-induced liver disease is one of the adverse reactions of clinical drugs. Acute liver injury is the most common form of drug-induced liver disease and even could cause life-threatening liver failure. It is not easy to diagnose, and the diagnosis can be established only after other diagnoses excluded. In most cases, patients usually are prescribed several drugs together, which makes it even harder to distinguish and give standardized treatment. This review summarizes the pathological category of Drug- induced liver disease and the mechanisms of action of liver-protecing drugs.

关 键 词：药物性肝病 保肝药物 作用机制 

分 类 号：R575[医药卫生—消化系统]