芳香烃受体及其配体调节溃疡性结肠炎Th17/Treg细胞分化的研究进展  

Aryl hydrocarbon receptor and its ligands for regulation of Th17/Treg cell differentiation in ulcerative colitis

作　　者：范恒[1] 徐萌[1] 唐庆[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院中西医结合科,湖北省武汉市430022

出　　处：《世界华人消化杂志》2015年第19期3101-3108,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81273908~~

摘　　要：溃疡性结肠炎(ulcerative colitis,UC)是一种肠道黏膜的慢性非特异性的炎症性疾病(inflammatory bowel disease,IBD),其发病机制与免疫细胞Th17/Treg的失衡有关.而芳香烃受体(aryl hydrocarbon receptor,Ah R)是一种细胞质内的转录因子,参与调节药物的代谢、细胞生长和分化,并且与机体免疫反应性疾病和炎症性疾病的发生密切相关.近年来的研究发现,活化的Ah R可调控UC患者体内Th17和Treg的分化.故本文就Ah R的结构、功能及其对溃疡性结肠炎患者的Th17/Treg分化的影响作一综述.Ulcerative colitis（UC） is a chronic,non-specific intestinal mucosal inflammatory disease,and its pathogenesis is related to the imbalance ofTh17/Treg.The aryl hydrocarbon receptor（AhR） is a cytoplasmic transcription factor,which is involved in the regulation of drug metabolism,cell growth and differentiation,and is closely related to the occurrence of autoimmune disease and inflammatory disease.Recent studies have found that activation of Ah R can regulate the differentiation of Th17/Treg in UC patients.This paper reviews the structure and function of AhR and its effect on differentiation of Th17/Treg in UC.

关 键 词：溃疡性结肠炎 芳香烃受体 配体 T淋巴细胞 免疫 

分 类 号：R574.62[医药卫生—消化系统]