骨转移性小细胞癌11例穿刺病理的鉴别诊断  

Differentail diagnosis of metastatic small cell carcinoma of bone in needle biopsy: an analysis of 11 cases

作　　者：田萌萌[1] 孙晓淇[1] 张铭[1] 赵蕾[1] 孟淑琴[1] 

机构地区：[1]北京积水潭医院病理科,100035

出　　处：《临床与实验病理学杂志》2015年第7期773-776,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨骨转移性小细胞癌穿刺病理的诊断与鉴别诊断,尤其是与骨原发Ewing肉瘤的鉴别诊断。方法收集11例骨转移性小细胞癌和20例骨原发Ewing肉瘤的临床病理资料,并采用免疫组化En Vision两步法检测两组病例中相关标志物的表达。结果 11例骨转移性小细胞癌中,CD99阳性率27.3%,FLI-1阳性率54.5%;20例骨原发Ewing肉瘤中,CK阳性率15.0%。患者年龄、单发病灶、免疫组化标志物CK、vimentin、CD99、FLI-1、CD56的表达在两组间差异具有显著性。结论骨转移性小细胞癌与骨原发Ewing肉瘤的组织形态相似,免疫组化标志物的表达也有重叠,正确诊断需结合临床资料及免疫组化染色综合分析。Purpose To investigate the diagnosis and differentail diagnosis of metastatic small cell carcinoma of bone in needle biopsy, especially for the differentail diagnosis with Ewing sarcoma of bone. Methods Clinicopathological informations of 11 cases of metastat-ic small cell carcinoma and 20 cases of Ewing sarcoma were collected, and markers for differentail diagnosis were detected in two groups by immunohistochemistry of EnVision. Results The positive rates of CD99 and FLI-1 were 27. 3% and 54. 5% in metastatic small cell carcinoma group, while the positive rate of CK was 15. 0% in Ewing sarcoma group. Patient′s age, single lesion, expression of CK, vimentin, CD99, FLI-1, CD56 were significantly different in two groups. Conclusions Metastatic small cell carcinoma and E-wing sarcoma share similar histopathologic features in needle biopsy, no single immunohistochemical marker can specifically distinguish small cell carcinoma from Ewing sarcouma. The correct diagnosis should comprehensive analyze clinicopathologic characters and a se-ries of immunohistochemical markers.

关 键 词：小细胞肿瘤 骨转移 EWING肉瘤 鉴别诊断 免疫组织化学 

分 类 号：R738.1[医药卫生—肿瘤]