中药熏洗联合谷胱甘肽预防奥沙利铂神经毒性42例  

作　　者：王冬梅[1] 庞瑞[1] 孙永强[1] 

机构地区：[1]新疆医科大学附属肿瘤医院中西医结合科,新疆乌鲁木齐830011

出　　处：《实用中医药杂志》2015年第8期741-742,共2页Journal of Practical Traditional Chinese Medicine

摘　　要：目的:观察中药熏洗联合还原型谷胱甘肽防治奥沙利铂周围神经毒性的作用。方法:72例随机分为对照组和治疗组,对照组30例在每次奥沙利铂化疗前1h给予还原谷胱甘肽3g静滴0.5h,治疗组42例在对照组疗法基础上,自化疗前1天开始给予温阳活血通络方熏蒸/浸泡四肢,每日1次,连用7天,两组治疗6周期后观察疗效。结果:治疗组的奥沙利铂神经毒性发生率与严重程度情况均明显低于对照组(P<0.05),结论:温阳活血通络方熏洗联合还原型谷胱甘肽能有效减轻奥沙利铂周围神经毒性。Objective： To observe the effect of Chinese fumigation and washing therapy combined with glutathione in preventing and treating the neurotoxicity induced by oxaliplatin. Method： 72 patients were randomly divided into 2 groups, 30 cases in the control group and 42 cases in the treatment group. The patients in the control group were received of 3g of GSH intravenously in 30 min before chemotherapy with oxaliplatin while the patients in the treatment group were additionally received Chinese fumigation and washing therapy 1 day before chemotherapy with oxaliplatin, once a day for 7 days. The incidence and severity of oxaliplatin-induced neurotoxicity were observed after six weeks of chemotherapy. Result： The neurotoxicity incidence and severity in the treatment group were significantly lower than that in the control group （ P〈0.05 ） . Conclusion： Chinese fumigation and washing therapycombined with GSH is effective in preventing the neurotoxicity incidence and reliving the neurotoxicity severity induced by oxaliplatin.

关 键 词：温阳活血通络方 还原型谷胱甘肽 奥沙利铂 神经毒性 

分 类 号：R745.49[医药卫生—神经病学与精神病学]