术后^(131)I治疗对甲状腺癌唾液腺功能与甲状腺球蛋白抗体影响  

Postoperative ^(131)I effect of salivary gland function and thyroglobulin antibody for thyroid carcinoma

作　　者：林旭辉[1] 敖平[1] 

机构地区：[1]惠州市第三人民医院普外科,广东惠州51600

出　　处：《岭南现代临床外科》2015年第4期426-428,共3页Lingnan Modern Clinics in Surgery

摘　　要：目的探讨术后131I治疗对甲状腺癌唾液腺功能与甲状腺球蛋白抗体(Tg Ab)影响。方法我院甲状腺癌手术后接受131I治疗患者79例,其中40例患者给予150 m Ci 131I治疗(150 m Ci组),39例给予80 m Ci8 131I治疗(80 m Ci组),比较两组唾液腺功能和Tg Ab水平的差异。结果 150 m Ci组治疗有效率稍高于80 m Ci组,但两组比较差异无统计学意义(P>0.05),150 m Ci组唾液初始p H值与唾液缓冲p H值明显高于80 m Ci组,唾液流率明显低于80 m Ci组,两组比较差异具有统计学意义(P<0.05),131I治疗后3、6个月,150 m Ci组平均Tg Ab水平明显低于80 m Ci组(P<0.05)。结论术后131I治疗对甲状腺癌临床疗效显著,其中低剂量131I治疗对唾液腺不良反应程度较低,而高剂量131I治疗有助于Tg Ab水平的降低。Objective To investigate the effect of the postoperative^131 Ⅰtreatment on salivary gland function and Thyroglobulin antibody（Tg Ab） for thyroid carcinoma. Methods Seventy-nine cases of thyroid carcinoma surgery patients in our hospital were included. Forty patients were treated with 150 m Ci %131Ⅰ（150 m Ci group） and thirty-nine patients with 80 m Ci ^131Ⅰ（80 m Ci group）. Salivary gland function and Tg Ab levels of patients were compared between the two groups. Results Effective rate of 150 m Ci group was slightly higher than of 80 m Ci group, but it had not statistically significant difference between the two groups. Saliva p H value and salivary buffer p H value of 150 m Ci group were significantly higher than 80 m Ci group. Salivary flow rate was significantly lower than 80 m Ci group（P〈0.05）,and 3,6 months after ^131 Ⅰ therapy, the average Tg Ab of 150 m Ci group were significantly lower than 80 m Ci group（P〈0.05）. Conclusion In our study, the effect of131 I therapy was remarkable for treatment of thyroid carcinoma, and it had less adverse reaction in low dose ^131Ⅰtherapy, but the Tg Ab more dropping degree in high dose ^131Ⅰ therapy.

关 键 词：^131I 甲状腺癌 唾液腺功能 甲状腺球蛋白抗体 

分 类 号：R736.1[医药卫生—肿瘤]