术前中性粒细胞与淋巴细胞比值对胰腺癌预后的判断价值  

Preoperative neutrophil-lymphocyte ratio as an independent prognostic predictor for pancreatic cancer

作　　者：吴永杰[1] 刘海亮[1] 胡明根[1] 赵之明[1] 薛瑞华[1] 刘荣[1] 

机构地区：[1]解放军总医院肿瘤外二科,北京100853

出　　处：《中华医学杂志》2015年第28期2291-2293,共3页National Medical Journal of China

摘　　要：目的 探讨术前外周血中性粒细胞与淋巴细胞比值（NLR）对胰腺癌预后的影响.方法 回顾性分析65例胰腺癌根治性手术患者的临床病理资料,按照术前NLR值将NLR≥2.4和NLR＜ 2.4定义为高低两组,采用Kaplan-Meier法分析胰腺癌术后1年生存率,单因素分析及Cox比例风险回归模型分析两组病例的临床病理情况及NLR与术后1年生存率的关系.结果 高NLR组和低NLR组术后1年生存率分别为64.5％和73.5％,差异有统计学意义.高NLR是影响胰腺癌术后死亡风险的独立危险因素（RR：1.417;95％ CI：1.065～1.886;P =0.017）.结论 术前NLR对胰腺癌预后的预测有临床意义.Objective To evaluate the impact value of preoperative neutrophil-lymphocyte ratio （NLR） for the prognosis of pancreatic cancer patients.Methods The clinical data of 65 patients with resectable pancreatic cancer were analyzed retrospectively.According to preoperative NLR,the patients were divided into high group （NLR ≥2.4）and low group（NLR ＜ 2.4）.Caner-specific survival was assessed using the Kaplan-Meier method.The 1-year survival rates and the clinic pathological factors in the two groups were analyzed using univariate analysis and COX regression model.Results The 1-year survival rate of higher NLR group and lower NLR group was 64.5％ and 73.5％ respectively,with statistic significance.A high NLR was identified as an independent risk factor of poorer prognosis for patients with pancreatic cancer （RR：1.465;95％ CI：1.078-1.993;P =0.015）.Conclusion Preoperative NLR can be a clinically significant factor for the assessment of prognosis of Pancreatic Cancer.

关 键 词：胰腺肿瘤 中性粒细胞/淋巴细胞比值 预后 

分 类 号：R735.9[医药卫生—肿瘤]