胰腺腺泡细胞癌临床病理观察  

Clinicopathological features of pancreatic acinar cell carcinoma

作　　者：崔素萍[1] 万鸿飞[1] 田澄[1] 刘红刚[1] 

机构地区：[1]首都医科大学附属同仁医院病理科,北京100730

出　　处：《诊断病理学杂志》2015年第7期410-413,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨腺泡细胞癌的临床病理特点、免疫组化表型及诊断与鉴别诊断。方法复习1例腺泡细胞癌的临床资料,行组织学观察和免疫组化分析,并复习相关文献。结果患者女性,42岁。腹部CT发现胰腺占位,肝多发性实性占位,腹腔淋巴结肿大。胰腺肿物位置较深,受周围器官影响,只能行肝肿物穿刺。穿刺组织显示肿瘤细胞呈腺泡状、实性排列,可见坏死。免疫组化:CK7、CK8/18、CK19、α-AAT和α-ACT(+)。结论腺泡细胞癌不仅腺泡分化标记物α-AAT,α-ACT和CK8/18等可以(+),胰腺导管分化标记物CK7和CK19等也可以(+)。Objective To investigate the clinicopathologic features,diagnosis,differential diagnosis of the pancreatic acinar cell carcinoma. Methods Review of clinical data,histological observation and immunohistochemical analysis were conducted in one case of pancreatic acinar cell carcinoma. Results CT scan of the abdomen demonstrated a pancreatic mass and multiple liver masses,with celiac Lymph node enlargement in a 42-years old female. Since the pancreatic mass located in the deep of celiac cavity,affected by organs arrounding; it was difficult to get a biopsy,and only a liver mass puncture was avaliable with ultrasonic guidance. The liver specimen showed that tumor cells arranged in acinar pattern and solid pattern,with visible necrosis. Immunohistochemically,the tumor cells were positive for CK7,CK8 /18,CK19,α-AAT,and α-ACT. Conclusion Acinar cell carcinoma may not only express both biomarkers of acinar differentiation like α-AAT,α-ACT,and CK8 /18,but also other biomarkers of pancreatic ductal differrention such as CK7 and CK19.

关 键 词：腺泡细胞癌 病理诊断 鉴别诊断 免疫组化 

分 类 号：R735.9[医药卫生—肿瘤]