急性冠脉综合征患者冠脉病变程度与患者血清促炎因子相关性分析  

Correlation analysis of acute coronary syndrome severity in patients with coronary lesions and serum proinflammatory factor

作　　者：庄晓华[1,2] 陆铭[1,2] 凌佳[1,2] 阚丽虹[1,2] 汪飞[1,2] 王志华[1,2] 陈惠君[1,2] 李晓鸣[1,2] 蔡振荣[1,2] 罗心平[3] 

机构地区：[1]上海市浦东医院 [2]复旦大学附属浦东医院心内科,上海201399 [3]复旦大学附属华山医院心内科,上海200040

出　　处：《贵州医药》2015年第6期496-498,共3页Guizhou Medical Journal

基　　金：上海市卫生计生委课题[项目编号:20124232]

摘　　要：目的探讨急性冠脉综合症患者冠脉病变程度与血清促炎因子IL-1、IL-2、IL-4、IL-6、IL-8、TNF-α水平变化关系。方法选取2013年1月至2014年6月在我院住院诊治的急性冠脉综合征患者120例作为观察组,同期选取我院健康体献血者40例作为对照组,采用双抗体夹心法酶联免疫吸附试验(ELISA)测定血清IL-1、IL-2、IL-4、IL-6、IL-8、TNF-α浓度,并在行冠状动脉造影后计算冠状动脉病的病变支数和Gennisi评分。结果急性冠脉综合征患者IL-1、IL-2、IL-4、IL-6、IL-8、TNF-α水平高于正常健康者,差异均有统计学意义(P<0.01);冠脉病变支数和促炎细胞因子IL-1、IL-2、IL-4、IL-6、IL-8和TNF-α水平呈正相关(P<0.01);冠脉病变积分和促炎细胞因子IL-1、IL-2、IL-4、IL-6、IL-8和TNF-α水平成正相关(P<0.01);IL-1、IL-2、IL-4、IL-6、IL-8、TNF-α之间存在正相关(P均<0.01)。结论测定急性冠脉综合征患者促炎因子水平可对观察患者冠脉病变程度提供有价值的参考依据。Objective To investigate the extent of coronary lesions in patients with acute coronary syndrome and serum inflammatory factor IL-1 ,promoting the relationship between changes levels of IL-2 ,IL-4 ,IL-6 ,IL-8 ,TNF-α. Method From 2013 April to 2014 June in acute coronary or outpatient treatment in our hospital in patients with syn-drome of 120 cases as the observation group ,the same period in our hospital were chosen healthy body donors in 40 cases as control group ,using double antibody sandwich enzyme linked immunosorbent assay （ELISA） for determina-tion of serum IL-1 ,IL-2 ,IL-4 ,IL-6 ,IL-8 ,TNF-αconcentration ,and undergoing coronary angiography after coronary artery disease lesions calculated count and Gensini score.Result The patients with acute coronary syndrome IL-1 ,IL-2 ,IL-4 ,IL-6 ,IL-8 ,TNF-αis higher than normal healthy people ,the difference was statistically significant （P〈0.01）;coronary lesions and proinflammatory cytokines IL-1 ,IL-2 ,IL-4 ,IL-6 ,IL-8 and TNF-αlevels were positively correlated （P〈0.01）;coronary artery lesion score and proinflammatory cytokines IL-1 ,IL-2 ,IL-4 ,IL-6 ,IL-8 and TNF-αlevels are positively correlated （P〈0.01）;there is a positive correlation between IL-1 ,IL-2 ,IL-4 ,IL-6 ,IL-8 ,TNF-α （P〈0.01）.Conclusion The determination of syndrome treated with proinflammatory cytokine levels can provide valuable reference for the degree of coronary stenosis in patients with acute coronary.

关 键 词：急性冠脉综合征 促炎细胞因子 冠脉病变程度 

分 类 号：R-33[医药卫生] R541.4