婴儿色素性神经外胚层瘤1例并文献复习  

A case of melanotic neuroectodermal tumor of infancy and review of literature

作　　者：毛静静[1] 徐兴侨[1] 王彦亮[1] 周稚辉[1] 郎淼杰 

机构地区：[1]温州医科大学附属口腔医院,325027

出　　处：《实用口腔医学杂志》2015年第4期584-587,共4页Journal of Practical Stomatology

摘　　要：笔者报告1例婴儿色素性神经外胚层瘤(MNTI):3月大男婴,发现右上颌骨处肿物半月,行肿物切除术,并刮除累及牙胚和骨质。镜下示肿瘤含上皮样细胞和神经母细胞,免疫组化示上皮样细胞HMB-45、CK、EMA、Vim阳性,神经母细胞S100、NSE、GFAP、Vim阳性。术后18个月密切随访,未发现复发转移。对相关文献进行了复习讨论。This paper reports a case of melanotic neuroectodermal tumor of infancy （MNTI） arising in the maxilla of a 3-month-old male infant. The treatment included surgical excision of the lesion with safe margin, curettage of the maxilla and removal of associated developing tooth bud. Microscopically,it proved to be a dual tumor with small, neuroblastic-like cells and larger epithelia/ceils. Immunohistochemiea/ staining demonstrated epitheloid cells HMIM5 （ ＋ ）, EMA（ ＋ ）, CK（ ＋ ） ;neuroblast-like cells NSE （ ＋ ）, GFAP（ ＋ ）, S-100 （ ＋ ）, but both cells Vim（ ＋ ） , CD45（ - ） , Myogenin（ - ）. The 18-month follow-up showed no recurrence or metastasis. The related literature was re- viewed.

关 键 词：婴儿 上颌骨 婴儿色素性神经外胚层瘤(MNTI) 免疫组化 

分 类 号：R739.8[医药卫生—肿瘤]