广泛期小细胞肺癌血浆纤维蛋白原、D-二聚体水平及血小板计数与患者近期疗效的相关性研究  

Correlative study on plasma levels of fibrinogen,D-dimer,platelet count and short-term effect in patients with extensive stage small lung cancer

作　　者：张亚雷[1] 何绮华[1] 杨海虹[1] 何建行[1] 

机构地区：[1]广州医科大学附属第一医院胸外科广州呼吸疾病研究所,广东广州510120

出　　处：《赣南医学院学报》2015年第3期379-382,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:探讨广泛期小细胞肺癌患者血浆纤维蛋白原、D-二聚体水平及血小板计数与其一线治疗疗效的相关性。方法:测定61例广泛期小细胞肺癌患者(肺癌组)及60例健康体检者(对照组)血浆纤维蛋白原、D-二聚体水平及血小板计数并进行对比及与一线治疗疗效的相关性分析。结果:肺癌组血浆纤维蛋白原、D-二聚体水平及血小板计数高于对照组(P<0.05),肺癌组血浆纤维蛋白原、D-二聚体水平及血小板计数与年龄、性别、吸烟史、有无脑转移、肺转移、胸膜转移、肾上腺转移之间无明显关系,在肝转移和骨转移患者中FIB水平显著升高(P<0.05)。广泛期小细胞肺癌患者血浆纤维蛋白原、D-二聚体水平及血小板计数与一线治疗后无进展生存时间呈负相关,其中血浆FIB含量与中位PFS呈显著负相关。结论:广泛期小细胞肺癌患者血液处于高凝状态,血浆纤维蛋白原、D-二聚体水平及血小板计数与患者的近期疗效密切相关。Objective： To explore the relationship between plasma levels of fibrinogen and D-dimer and platelet count and short-term effect in patients with extensive stage small lung cancer（ ES-SCLC）. Methods：The plasma levels of fibrinogen and D-dimer and platelet count were detected in 61 patients with ES-SCLC and 60 normal controls. Results：The D-dimer and plasma fibrinogen and platelet count were significantly higher than those of normal controls（ P 〈 0.05 ）. The plasma levels of fibrinogen and D-dimer and platelet count in patients with ES-SCLC were not related to the age, sex, smoking history, brain metastasis, lung metastasis, pleural metastasis and adrenal metastasis, and were negatively correlated to the progression-free survival（PFS）. Conclusion：The hypereoagulability state exists in the patients with ES-SCLC. The plasma levels of fibrinogen and D-dimer and platelet count in the patients with ES-SCLC are correlated with the short-term effect.

关 键 词：小细胞肺癌 纤维蛋白原 D-二聚体 血小板计数 

分 类 号：R734.2[医药卫生—肿瘤]