肿瘤坏死因子-α基因启动子238位点单核苷酸多态性与脑梗死易感性的Meta分析  

The association of polymorphic 238 locus of TNF-α promoter with cerebral infarction:a meta-analysis

作　　者：余锋[1] 陈银河[2] 刘晓敏[1] 申才良[3] 

机构地区：[1]安徽医科大学附属省立医院神经内科,安徽合肥230001 [2]安徽医科大学附属阜阳医院骨科,安徽阜阳236000 [3]安徽医科大学第一附属医院脊柱外科,安徽合肥230022

出　　处：《中华疾病控制杂志》2015年第7期720-725,共6页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81472088);安徽省教育厅自然研究项目(2006KJ376B)

摘　　要：目的探讨肿瘤坏死因子（tumor necrosis factor,TNF）-α基因启动子区238位点单核苷酸多态性（single nucleotide polymorphism,SNP）与脑梗死（cerebral infarction,CI）易感性的关联情况。方法通过中国生物医学文献数据库、中国期刊网全文数据库、万方、维普,PubMed、Cochrane图书馆、OvidSP、Wiley Online图书馆、EBSCO、Elsevier Science Direct、Springer Link数据库检索TNF-α-238位点SNP与CI相关的病例-对照研究,利用RevMan 5.3和Stata 12.0软件对各研究数据进行综合统计分析。结果共纳入10篇文献,包括4 042例CI患者和3655例对照。CI组与对照组相比,GG基因型频率（OR=0.72,95%CI：0.55-0.96,P=0.020）、G等位基因频率（OR=0.69,95%CI：0.50-0.95,P=0.020）、A等位基因频率（OR=1.46,95%CI：1.06-2.01,P=0.020）差异有统计学意义,提示携有GG基因型和G等位基因者罹患CI的风险降低、携有A等位基因者罹患CI的风险增高。结论TNF-α基因启动子区238位点SNP与CI易感性之间有关联性。Objective To explore the association of the single nucleotide polymorphism（SNP） in-238 locus of tumor necrosis factor（TNF）-α promoter with cerebral infarction（CI）.Methods Chinese National Knowledge Infrastructure,Wanfang,Weipu,Pub Med,Cochrane Library,Ovid SP,Wiley Online Library,EBSCO,Elsevier Science Direct,Springer Link databases were searched for the association study of TNF-α-238 SNP with CI.Rev Man 5.3 and Stata 12.0software were used to make comprehensive statistical analysis of each research data.Results 10 studies including 4 042 CI patients and 3 655 controls were included.The frequencies of genotype GG（OR = 0.72,95% CI： 0.55-0.96,P =0.020）,allele G（OR = 0.69,95% CI： 0.50-0.95,P = 0.020） and allele A（OR = 1.46,95% CI： 1.06-2.01,P =0.020） had statistical difference between CI group and the control group; it indicating that carriers of genotype GG and allele G had lower risk of CI,carriers of allele A had higher risk of CI.Conclusions The meta analysis reveals that TNF-α-238 SNP is associated with the susceptibility to CI.

关 键 词：脑梗死 肿瘤坏死因子 多态性 单核苷酸 META分析 

分 类 号：R743.33[医药卫生—神经病学与精神病学]