mmp-14和CD34在青年乳腺癌演变过程中的表达及意义  

Expressions of matrix metalioproteinases-14 and CD34 in evolution of breast cancer in youth and its clinical significance

作　　者：王倩[1] 罗凯[2] 劳淑贞[1] 王敏[1] 张琼[1] 侯敏[1] 谭小军[1] 朴金松[1] 高蔚樱[1] 何利珍[1] 

机构地区：[1]广州医科大学附属肿瘤医院病理科,510065 [2]广州医科大学附属肿瘤医院肿瘤研究所,510065

出　　处：《国际医药卫生导报》2015年第15期2125-2128,共4页International Medicine and Health Guidance News

基　　金：广州市医药卫生科技项目（2014A011095）

摘　　要：目的研究基质金属蛋白酶14（mmp-14）与CD34在≤35岁乳腺癌、乳腺良性肿瘤、乳腺增生症及乳腺癌旁组织患者中的表达及临床意义。方法采用免疫组织化学方法对30例乳腺癌、30例乳腺良性肿瘤、30例乳腺增生症及30例癌旁组织中乳腺终末导管及腺泡上皮细胞患者的rnmp-14表达情况及CD34标记的间质血管数目进行检测。结果mmp-14在4组导管及腺泡上皮细胞中的表达情况：乳腺癌组mmp-14高表达，与其他3组两两比较差异具统计学意义（P〈0．05）。CD34在4组中标记问质血管数目的情况：乳腺增生症组和乳腺癌组血管增生数目均高于良性肿瘤组，差异有统计学意义（P〈0．05）。结论乳腺终末导管及腺泡上皮细胞mmp-14的高表达和CD34标记的间质血管数目增加与青年乳腺癌的演变过程密切相关，有望成为青年乳腺癌早期诊断和治疗可靠的临床指标。Objective To study the expressions of matrix metalloproteinases-14 （mmp-14） and CD34 in breast cancer, breast benign tumor, mammary gland hyperplasia, and para-carcinoma tissue in patients not over 35 years old and its clinical significance. Methods Immunohistochemical method is used to detect the expressions of romp-14 in the terminal breast ducts and acini epithelial ceils in 30 patients with breast cancer, 30 with breast benign tumor, 30 with mammary hyperplasia, and 30 with para-careinoma tissue. And the interstitial blood vessel number marked by CD34 is counted at the same time. Results The expression of romp-14 was significantly higher in breast cancer than in the other three groups （P〈0.05）. The expression of CD34 and the number of interstitial blood vessels marked by CD34 were significantly higher in breast cancer and mammary gland hyperplasia than in breast benign tumor （P〈0.05）. Conclusions The high expression of mmp-14 in terminal breast ducts and acini epithelial cells and the increase in interstitial blood vessel number marked by CD34 correlate with the evolution of breast cancer in youth could be used for early diagnosis and clinical reliable indicators for the treatment of breast cancer in youth.

关 键 词：基质金属蛋白酶-14 CD34 免疫组织化学 乳腺癌 青年 

分 类 号：R737.9[医药卫生—肿瘤]