脂质代谢紊乱导致非酒精性脂肪性肝病的发病机制  

Roles of abnormal lipid metabolism in pathogenesis of non- alcoholic fatty liver disease

作　　者：路然 洪天配[1] 

机构地区：[1]北京大学第三医院内分泌科,北京100191

出　　处：《临床肝胆病杂志》2015年第7期1050-1054,共5页Journal of Clinical Hepatology

基　　金：国家973计划资助项目(2012CB517502)

摘　　要：随着肥胖、2型糖尿病、脂代谢紊乱等代谢性疾病的患病率在世界范围内快速升高,非酒精性脂肪性肝病(NAFLD)患病率也随之升高。大多数NAFLD患者表现为单纯性肝脏脂肪变性,但部分患者会进展为非酒精性脂肪性肝炎、肝硬化、肝癌等。在发达国家,NAFLD已成为肝酶升高的最常见原因,日益受到人们的关注。由于肝脏脂肪沉积是NAFLD的核心表现,就脂质代谢异常在NAFLD中的作用及其潜在机制进行了综述,指出阐明NAFLD的发病机制将有助于制订有针对性的预防和治疗策略。The prevalence of non- alcoholic fatty liver disease（ NAFLD） keeps rising worldwide along with the increasing prevalence of metabolic diseases such as obesity,type 2 diabetes,and dyslipidemia. Although most NAFLD patients present with simple steatosis of hepatocytes,some patients progress to non- alcoholic steatohepatitis,liver cirrhosis,and even cancer. In the Western world,NAFLD is the most common cause of elevated liver enzymes,and hence there has been a growing interest in this disease. Given that fat deposition in the liver is the hallmark of NAFLD,we review the roles and the underlying mechanism of disturbed lipid metabolism in the development of NAFLD and suggest that more insights into the pathogenesis of NAFLD will help develop targeted strategies for the prevention and treatment of this disease.

关 键 词：脂肪肝 脂代谢障碍 炎症 

分 类 号：R575.5[医药卫生—消化系统]