脑白质疏松患者静息态脑网络磁共振成像的研究  

Resting-state Network of Brain in Leukoaraiosis Patients: A Magnetic Resonance Imaging Study

作　　者：魏娜[1] 燕浩[3] 白丽君[4] 姚婧璠[1] 李越秀[1] 陈红燕[2] 张玉梅[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经内科,北京市100050 [2]首都医科大学附属北京天坛医院,医学影像中心,北京市100050 [3]西安电子科技大学英语系、心理系,陕西西安市710126 [4]西安交通大学生命科学与技术学院,陕西西安市710049

出　　处：《中国康复理论与实践》2015年第7期793-798,共6页Chinese Journal of Rehabilitation Theory and Practice

基　　金：北京师范大学认知与学习国家重点实验室开放课题;国家自然科学基金项目(No.81371201);北京市卫生系统高层次卫生技术人才项目(No.2011-3-024);北京市委组织部优秀人才培养资助项目(No.KM201310025019)

摘　　要：目的观察脑白质疏松(LA)患者与健康人静息态脑网络的差异。方法分别对根据临床诊断的31例LA患者及27名年龄匹配的健康对照者进行静息态功能磁共振扫描,采用独立成分分析法分离静息状态专属性功能脑网络。结果患者组及对照组中均发现与以往文献报道相同的静息网络。两者的脑激活区域基本一致,但患者组网络成分的激活程度均较对照组低,包括楔前叶、扣带回后部、颞上回、顶上回、中央前回、中央后回、岛叶、前额叶皮质等。结论 LA患者与健康人在脑静息网络激活程度上存在显著差异。Objective To explore the diversity of resting-state network of brain between the patients with leukoaraiosis and the healthy people. Methods 31 patients with leukoaraiosis （patients） and 27 healthy persons （controls） were checked with resting-state functional mag-netic resonance imaging （rs-fMRI）, and analyzed with the independent component analysis （ICA） to explore the resting-state functional brain network. Results The resting-state brain network was found in both the patients and the controls, which was coincident with the previ-ous studies. The active areas were the same in both groups, and the activation was weaken in the patients than in the controls, especially in quadrate gyri, posterior cingulate cortex, superior temporal gyrus, superior parietal gyrus, anterior central gyrus, post central gyrus, insula and prefrontal cortex. Conclusion There is a significant diversity of resting-state network of brain between the patients with leukoaraiosis and healthy people in the activation of active areas.

关 键 词：脑白质疏松 静息态脑网络 默认网络 功能磁共振成像 独立成分分析 

分 类 号：R742[医药卫生—神经病学与精神病学]