积雪草提取物对大鼠心肌保护作用的实验研究  

Experimental Study on Myocardial Protective Effect of Centella Asiatica Extract on rats

作　　者：王策[1] 

机构地区：[1]南阳医学高等专科学校

出　　处：《按摩与康复医学》2015年第12期138-140,共3页Chinese Manipulation and Rehabilitation Medicine

基　　金：河南省南阳市2012年科技发展计划,编号:2012GG066

摘　　要：目的：探讨积雪草提取物预处理对大鼠缺血再灌注损伤心肌的保护作用.方法：将27只SPF级Wistar大鼠随机分为假手术组、模型组、积雪草提取物预处理组;除假手术组外,均制作大鼠心肌缺血再灌注模型,分别测定各组大鼠心肌组织中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、乳酸脱氢酶（LDH）、肌酸激酶同工酶（CK-MB）活性和丙二醛（MDA）含量,并观察心肌组织病理学变化.结果：与假手术组比,模型组心肌组织SOD、CAT、LDH及CK-MB活性均下降（P〈0.05）,MDA含量均升高（P〈0.05）;与模型组相比,积雪草提取物预处理组SOD、CAT、LDH及CK-MB活性均升高（P〈0.05）,MDA含量均降低（P〈0.05）.结论：积雪草提取物预处理能减轻大鼠心肌的缺血再灌注损伤,具有良好的心肌保护作用.Objective：To investigate the protective effect of centella asiatica extract pre-treatment on myocardium which was ischemical reperfusion injured in rats. Methods：27 SPF Wistar rats were randomly divided into sham operation （SO） group, model group, centella asiatica extract pre-treat-ment group;except the SO group, myocardial ischemia reperfusion models were established with rats in the rest groups, and tested the activities of SOD, CAT, LDH, CK-MB and content of MDA of rats＇ myocardial tissues in each group, and observed the pathological changes of myocardial tis-sues. Results：Compared with the SO group, the activities of SOD, CAT, LDH and CK-MB in myocardial tissues of model group were all decreased （P〈0.05）, the content of MDA was increased （P〈0.05）;Compared with the model group, the activities of SOD, CAT, LDH and CK-MB of centella asiatica extract pre-treatment group were all increased （P〈0.05）, the content of MDA was decreased （P〈0.05）. Conclusion：Centella asiatica extract pre-treatment group can alleviate the ischemical reperfusion injury of myocardium in rats, and has a good myocardial protective effect.

关 键 词：积雪草 缺血再灌注 心肌保护 预处理 

分 类 号：R-33[医药卫生]