Streptozotocin induced Alzheimer's disease like changes and the underlying neural degeneration and regeneration mechanism  

作　　者：Pradip Kumar Kamat 

机构地区：[1]Department of Anasthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine,University of Florida

出　　处：《Neural Regeneration Research》2015年第7期1050-1052,共3页中国神经再生研究（英文版）

基　　金：supported in part by the Council of Scientific and Industrial Research (CSIR), India;financial support to Pradip Kumar Kamat

摘　　要：Alzheimer’s disease（AD）is a neurodegenerative disorder which is remarkably characterized by pathological hallmarks that include neurofibrillary tangles,neuronal loss extracellular senile plaques containing aggregated amyloid beta（Aβ）,and neurofibrillary tangles composed of the hyperphosphorylated form of the microtubule protein tau.It is the most common form of dementia which is characterized by severe neurodegenerative changes such as loss of neurons and synapses in brain（Kamat et al.,2014）.Alzheimer’s disease（AD）is a neurodegenerative disorder which is remarkably characterized by pathological hallmarks that include neurofibrillary tangles,neuronal loss extracellular senile plaques containing aggregated amyloid beta（Aβ）,and neurofibrillary tangles composed of the hyperphosphorylated form of the microtubule protein tau.It is the most common form of dementia which is characterized by severe neurodegenerative changes such as loss of neurons and synapses in brain（Kamat et al.,2014）.

关 键 词：STZ Streptozotocin induced Alzheimer’s disease like changes and the underlying neural degeneration and regeneration mechanism AD 

分 类 号：R749.16[医药卫生—神经病学与精神病学]