甲状腺乳头状癌超声造影增强模式及与肿瘤侵袭性的关系探讨  

Contrast enhanced ultrasonogrphy patterns in papillary thyroid carcinoma and correlation between degree of enhancement and tumor invasiveness

作　　者：崔秋丽[1] 刘文英[1] 李广涵 严昆[1] 杨薇[1] 陈敏华[1] 

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所超声科恶性肿瘤发病机制及转化研究教育部重点实验室,100142

出　　处：《中华超声影像学杂志》2015年第7期580-583,共4页Chinese Journal of Ultrasonography

基　　金：首都卫生发展科研专项项目（首发2011-2015-01）;北京市卫生系统高层次卫生技术人才培养计划（2（）13-3-086）

摘　　要：目的探讨甲状腺乳头状癌超声造影增强模式及其增强程度与肿瘤侵袭性的关系。方法对经手术病理证实的161例患者共73个甲状腺乳头状癌病灶术前行超声造影检查，对超声造影增强模式进行分析；比较不同增强程度甲状腺乳头状癌其包膜和周围组织侵犯及淋巴结转移的差异。结果73个甲状腺乳头状癌灶中超声造影表现低增强52个（71．2％），等增强13个（17．8％），高增强8个（11．0％）。52个低增强的病灶中包膜侵犯23个（44．2％），等增强及高增强21个病灶中包膜侵犯15个（71．4％），两者比较差异具有统计学意义（P〈0．05）。低增强52个病灶中淋巴结转移25个（48．1％），等增强及高增强21个中淋巴结转移13个（61．9％），两者比较差异无统计学意义（P〉0．05）。结论超声造影不同增强程度与甲状腺乳头状癌侵袭性相关，等增强及高增强者更多出现包膜侵犯。Objective To study the enhanced patterns of papillary thyroid carcinoma （PTC） on contrast-enhanced ultrasound（CEUS）,and explore the relationship between the degree of enhancement and extracapsular invasionand cervical lymph node metastasis of the tumor. Methods Seventy-three PTCs in 61 patients selected for thyroid surgery underwent conventional ultrasound andcontrast-enhanced ultrasound. The enhanced patterns were analyzed. The differences between different degree enhancement and extracapsular invasion and cervical lymph node metastasis of PTCs were compared. Results Seventy-three PTCs enhanced patterns showed that 52（71.2% ） nodules with hypoenhancement, 13 （17.8%） nodules with isoenhancement, 8 （ 11.0% ） nodules with hyperenhancement. Twenty-three （44.2%, 23/52 ） nodules with extracapsular invasion in hypoenhancing patterns, and 15 （71.4%, 15/21 ） nodules with extracapsular invasion in isoenhancing or hyperenhancing patterns. There were significant differences between them（ P 0.05）. Twenty-five （48.1%, 25/52） nodules with cervical lymph node metastasis in hypoenhancing patterns, and 13 （61.9%, 13/21） nodules with cervical lymph node metastasis in isoenhancing or hyperenhaneing patterns, there was no significant difference between them （ P 〉 0.05）. Conclusions The degree of enhancement are correlate to invasiveness in PTCs, PTCs with isoenhancement or hyperenhancement patterns were more often with extracapsular invasion.

关 键 词：超声检查 微气泡 甲状腺肿癌 腺癌 乳头状 肿瘤侵袭性 

分 类 号：R736.1[医药卫生—肿瘤]