苍耳子散加味方联合鼻腔冲洗对鼻咽癌放疗患者放射性鼻窦炎发生的影响  

Influence of Combination of Modified Cang'erzi San(苍耳子散) and Nasal Irrigation on Radiation Nasosinusitis in Patients with Nasopharyngeal Carcinoma Receiving Radiotherapy

作　　者：李泳文[1] 

机构地区：[1]河南省中医院河南省郑州市东风路6号,450020

出　　处：《中医杂志》2015年第15期1314-1317,共4页Journal of Traditional Chinese Medicine

摘　　要：目的观察苍耳子散加味方口服对鼻咽癌放疗患者放射性鼻窦炎的预防作用。方法选取接受放疗的鼻咽癌患者共102例,随机分为治疗组52例和对照组50例。对照组予以常规维生素B12鼻腔冲洗,治疗组在对照组基础上加用苍耳子散加味方口服,两组疗程均为4周。比较两组患者治疗前后临床症状积分及纤毛传输速率、鼻内镜和鼻窦CT评分,观察两组患者治疗后的临床疗效及放疗3个月、6个月内的放射性鼻窦炎发生率。结果治疗组临床疗效总有效率98.08%,对照组为82.00%,治疗组优于对照组(P<0.05)。两组患者治疗后鼻塞、鼻黏膜充血和鼻甲肿大、鼻腔分泌物、嗅觉减退和头痛评分明显低于治疗前,且治疗组优于对照组(P<0.05)。两组患者治疗后的纤毛传输速率、鼻内镜和鼻窦CT评分明显高于治疗前,且治疗组高于对照组(P<0.05)。治疗组放疗3个月及6个月内放射性鼻窦炎分别发生9例及11例,对照组分别为23例及28例,治疗组明显少于对照组(P<0.01)。结论苍耳子散加味方口服联合鼻腔冲洗可改善鼻咽癌放疗患者的鼻窦症状,预防放射性鼻窦炎的发生。nasosinusitis in nasopharyngeal Objective To observe the preventive effect of modified Cang＇erzi San （ patients with nasopharyngeal carcinoma receiving radiotherapy. Methods （苍耳子散 ） on radiation Totally 102 patients with carcinoma receiving radiotherapy were enrolled. They were randomly assigned into treatment of 52 cases and control group of 50 cases. The control group received conventional nasal irrigation with vitamin Bn. The treatment group was given oral modified Cang＇erzi San in addition to the therapy of control group. The course of the treatment were 4 weeks. The integrations of clinical symptom, ciliary transport rate and scores of nasal endoscope and paranasal sinus CT before and after treatment were compared. Clinical effect after treatment and the incidence of radiation nasosinusitis within 3 and 6 months after radiotherapy in both groups were observed. Results The effective rates were 98.08% and 82.00% in treatment and control group, respectively. The treatment group was more effective than control （P 〈 0. 05 ）. Developments of nasal congestion, nasal mucosal congestion, turbinate enlargement, nasal secretions and hyposmia and headache score after treatment were significantly lower than those before treatment in both groups. The treatment group had an advantage over control （ P 〈 0. 05）. Ciliary transport rate and scores of nasal endoscope and paranasal sinus after treatment were higher than those before treatment in both groups, and the treat- ment group was superior than control （P 〈 0. 05 ）. 9 and 11 cases of radiation nasosinusitis occurred in treatment group within 3 and 6 months after radiotherapy, respectively; while 23 and 28 cases occurred in control. The incidence in treatment group was significantly lower than that in control （P 〈 0. 01 ）. Conclusion Combination of modified Cang＇ erzi San and nasal irrigation can improve the sinonasal symptom in patients with nasopharyngeal carcinoma receiving radiotherapy, preventing the onset of radiation naso

关 键 词：鼻咽癌 放射疗法 放射性鼻窦炎 苍耳子散加味方 

分 类 号：R739.63[医药卫生—肿瘤]