宫颈癌中长链非编码RNA CRNDE表达及其临床意义  

Expression and clinical significance of long non-coding RNA CRNDE in cervical cancer

作　　者：韩懿[1] 劳美琼[1] 雷巧如 李艳娜[1] 

机构地区：[1]广东省开平市中心医院产科,广东省开平市529300 [2]广东省开平市中心医院妇科,广东省开平市529300

出　　处：《中国肿瘤临床》2015年第14期705-708,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨长链非编码RNA(Lnc RNA)CRNDE在宫颈癌中表达及其临床意义。方法:收集广东省开平市中心医院行手术切除的宫颈癌组织及癌旁组织标本87例,实时荧光定量PCR(RT-PCR)检测Lnc RNA CRNDE表达差异,分析其与临床病理特征的关系。结果:与癌旁组织比较Lnc RNA CRNDE在宫颈癌组织中呈高表达(P<0.05)。Lnc RNA CRNDE高表达与宫颈癌FIGO分期,淋巴结转移,肿瘤的侵袭深度相关。此外,Lnc RNA CRNDE高表达较低表达者的生存时间缩短(P<0.05)。Cox回归多因素分析发现Lnc RNA CRNDE可作为宫颈癌患者独立的预后因子。结论:Lnc RNA CRNDE可作为宫颈癌独立的预后标志物和潜在的治疗靶点。Objective： To investigate the expression and clinical significance of long non-coding RNA （LncRNA） CRNDE in cer- vical cancer. Methods： Specimens of cervical cancer tissues and matched non-tumor para-neoplastic tissues were collected from 87 pa- tients who underwent surgery in the Kaiping Central Hospital, China. Quantitative real-time PCR was used to examine the expression of LncRNA CRNDE, and its correlation with clinicopathological features was analyzed. Results： LncRNA CRNDE expression was sig- nificantly up-regulated in cervical cancer tissues than in adjacent non-tumor tissues （P〈0.05）. Increased LncRNA CRNDE expression was significantly correlated with FIGO stage, lymph node metastasis, and depth of cervical invasion （P〈0.05）. Moreover, a higher ex- pression of LncRNA CRNDE demonstrated significantly poorer overall survival in cervical cancer patients than in those with lower Ln- cRNA CRNDE expression （P〈0.05）. Multivariate analyses suggested that LncRNA CRNDE expression served as an independent pre- dictor for overall survival. Conclusion： Our findings posit that LncRNA CRNDE may be a potential prognostic marker and therapeutic target for cervical cancer.

关 键 词：长链非编码RNA CRNDE 宫颈癌 临床预后 

分 类 号：R737.33[医药卫生—肿瘤]