YAP与肿瘤干细胞相关性研究进展  

Advances in YAP on stemness maintenance of cancer stem cell Properties

作　　者：李海欣[1] 何娜[1] 郑红 

机构地区：[1]天津医科大学肿瘤医院肿瘤生物样本库、国家肿瘤临床医学研究中心、天津市肿瘤防治重点实验室,天津市300060 [2]流行病与生物统计学研究室

出　　处：《中国肿瘤临床》2015年第14期728-731,共4页Chinese Journal of Clinical Oncology

基　　金：教育部创新团队发展计划项目(编号:IRT_14R40);天津医科大学肿瘤医院院级课题(编号:1418)资助~~

摘　　要：YAP是一种多功能蛋白,可以与不同的转录因子相互作用激活基因的表达。YAP作为活化Hippo途径的关键转录调节蛋白在调节器官大小、细胞自我更新、干细胞和组织特异性祖细胞扩增等方面发挥重要作用,在Hippo途径中MST1/2激酶和其结合蛋白SAV共同磷酸化激酶LATS1/2,激活的LATS1/2磷酸化YAP从而抑制YAP蛋白的活性。近年来,大量的研究已经在胚胎干细胞、神经干细胞、造血干细胞中发现YAP的高表达能够维持干细胞干性并且已经成为维持干性的标志物,随后的研究发现信号通路可能与肿瘤干细胞(CSC)分化密切相关。本文主要讨论YAP在维持干细胞及肿瘤干细胞干性方面的作用。Yes-associated protein （YAP） is a multifunctional protein that can interact with different transcription factors to acti- vate gene expression. YAP, as the key transcription protein of Hippo pathway, has made important contribution to the control of the or- gan size, stem cell biology, and tissue-specific stem cell self-renewal. In the Hippo pathway, MST1/2 kinases, together with the adaptor protein SAV, phosphorylate LATS1/2 kinases. YAP is phosphorylated and inhibited by the activated LATS1/2, a key component of the Hippo tumor suppressor pathway. In recent years, numerous studies have shown that the high expression of YAP in the embryonic stem cells, neural stem cells, and hematopoietic stem cells can maintain the cancer stem cell; and YAP has become the marker of cancer stem cells. Meanwhile, more and more studies indicate that the disorder of Hippo-YAP signaling pathway may be associated with cancer stern cells. In this review, we mainly discuss the role of the Hippo pathway in the stem cell biology and its potential implications in tis- sue homeostasis and cancer.

关 键 词：YAP 干细胞 肿瘤干细胞 干性 

分 类 号：R730.2[医药卫生—肿瘤]