肺癌组织上皮膜抗原表达与预后相关性分析  

Expression of epithelial membrane antigen and its influence on the prognosis of patients with lung adenocarcinoma and squamous carcinoma

作　　者：李思文[1] 赵健[1] 傅文凡[1] 殷俊[1] 杨光平[1] 蓝永权 

机构地区：[1]广州医科大学附属肿瘤医院胸外科,广东广州510095

出　　处：《中华肿瘤防治杂志》2015年第13期1023-1027,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：广东省科技计划(2012B061700048);广州市卫生局项目(2013A011163);广州市中医药项目(20142A011023)

摘　　要：目的探讨上皮膜抗原（epithelial membrane antigen，EMA）在肺腺癌及肺鳞癌中的表达及其与患者临床因素和预后的关系。方法2007—06—15—2013—06—15广州医科大学附属肿瘤医院非小细胞肺癌（non-small cell lungcancer，NSCLC）手术标本110例，其中肺腺癌和肺鳞癌各55例。应用免疫组织化学法（immunohistochemistry，IHc）检测癌组织中EMA的表达，分析EMA与临床病理因素及预后的关系。结果llO例肺癌EMA表达阳性率为79．09％（87／110），高表达组为52．73％（58／110），其中肺腺癌为70．91％（39／55），高于肺鳞癌的34．54％（19／55），P〈0．001。EMA表达与病理类型（X2=14．589，P〈0．001）、分化程度（X2=9．246，P=0．002）、早期复发转移（X2=4．716，P=0．029）和肿瘤淋巴细胞浸润（X2=4．961，P=0．026）密切相关，与性别、年龄、家族史、吸烟史、肿瘤大小、临床分期、淋巴结转移和复发转移无明显相关。EMA高表达在I～ⅡA期肺鳞癌术后患者中提示预后差，P=0．026。结论肺癌组织EMA表达水平与肿瘤的病理类型、分化、侵袭及复发转移、肿瘤淋巴细胞浸润情况有关，与I～ⅡA期肺鳞癌预后相关，有可能成为早期肺鳞癌预后判断的指标。OBJECTIVE To investigate the expression of epithelial membrane antigen （EMA） in lung cancer inclu- ding adenocarcinoma and squamous carcinoma and evaluate its relationship with clinical factors and prognosis of patients. METHODS One hundred and ten lung cancer samples were collected between 2007-06-15 and 2013-06-15 from Cancer Center of Guangzhou Medical University, including 55 lung adenocarcinoma and 55 squamous carcinoma. Immumnohisto- chemistry assay was used to detetect EMA protein in tumor tissues. Its relationship with clinicopathological factors and prognosis were analyzed. RESULTS The positive rate of EMA＇s expression was 79.09%（87/110） in lung adenocarcino- ma and squamous carcinoma, in which the high expression rate was 52.73% （58/110）. The lung adenocarcinoma was 70. 91%（39/55）, which was higher than that of squamous carcinoma 34.54% （19/55, P〈0. 001）. The expression of EMA was closely connected with pathological type （X2 = 14. 589, P〈0. 001）, the degree of differentiation （）C = 9. 246, P=0. 002）, early recurrence metastasis （Xz =4. 716,P=0. 029）, tumor lymphocyte infiltration（xz =4. 961 ,P=0. 026）, and had no obvious correlation with gender, age, family history, smoking history, tumor size, tumor lymphocyte infiltra- tion, clinical stage, lymph node metastasis and recurrence metastasis. EMA high expression indicated a poor prognosis in I -- Ⅱ A stage lung squamous carcinoma （P=0. 026）. CONCLUSIONS EMA expression correlates pathological type of tumor, invasion and metastasis, tumor differentiation, lymphocyte infiltration conditions in NSCLC, it hint the prognosis of patients with I -- Ⅱ A lung squamous carcinoma, which has the potential to be one of prognostic indicators of early lung squamous carcinoma.

关 键 词：肺肿瘤 上皮膜抗原 临床病理因素 复发转移 预后 

分 类 号：R734.2[医药卫生—肿瘤]