广州地区孕妇羊水中PCBs暴露水平初步研究  

A Preliminary Study of PCBs Exposure Levels in Amniotic Fluid for Pregnant Women in Guangzhou

作　　者：陈致远[1,2] 郑铮 宋小飞[1] 

机构地区：[1]华南理工大学环境与能源学院,广州510006 [2]广州市番禺水务股份有限公司,广州511400 [3]广州市妇女儿童医疗中心,广州510623

出　　处：《生态毒理学报》2015年第3期248-255,共8页Asian Journal of Ecotoxicology

基　　金：广东省大气环境与污染控制重点实验室开放基金(2013hj003)

摘　　要：随机采集广州地区非职业PCBs(polychlorinated biphenyls,多氯联苯)暴露单胎孕妇分娩时羊水,分析羊水中PCBs浓度水平;结合孕妇临床资料(年龄、孕周、身体质量指数(body mass index,BMI))以及孕妇居住环境信息等,阐明了广州地区非职业暴露孕妇羊水PCBs蓄积的影响因素。结果表明,∑33PCBs浓度为15.91-324.38 ng·g-1,平均值为114.34±83.52 ng·g-1,中值为84.8 5ng·g-1;其中十氯含量最低,平均浓度为2.66±3.46 ng·g-1,中值为1.47 ng·g-1;六氯PCBs含量最高,平均浓度为28.79±33.84 ng·g-1,中值为17.48 ng·g-1。样本中有31种PCBs同分异构体在孕妇羊水中检出,分别为PCB 8、28、30、49、52、70、74、77、82、87、99、101、105、114、118、126、128、138、153、156、158、166、169、170、179、180、183、187、189、198和209;羊水主要的PCBs暴露以五氯PCBs、六氯PCBs和七氯PCBs为主,主要的同分异构体为PCB 138(4.73%)、179(4.15%)、153(3.92%)、183(3.89%)、166(3.77%)、187(3.74%)以及180(3.67%);暴露水平与美国、西班牙、加拿大等地区相比属于严重水平。统计结果显示,年龄、身体质量指数和孕周与PCBs蓄积有显著性正相关关系;工业区居住的孕妇相与非工业区居住孕妇相比,上述统计结果更为显著。Randomly collected fetal amniotic fluid of single pregnant women whom were not occupational exposure to PCBs in Guangzhou, then analyzed PCBs exposureslevels; Subjects＇ information such as clinical data （age, gesta- tional age, BMI （body mass index, BMI）） and resident information was also collected forillustrating influence fac- tors of PCBs exposure to pregnant women in Guangzhou. Results showed that ∑13PCBs concentrations in the amni-otic fluid ranged from 15.91 to 324.38 ng.g1. Theaverage value was 114.34 ±83.52 ng·g-1, and the median value was 84.85 ng·g-1. Decachlorobiphenyl exposure wasfound to be the lowest with an average value of 2.66±3.46 ng·g-1 and median value of 1.47 ng·g-1. Hexachlorobenzene were the highest （average value 28.79± 33.84 ng·g-1, me- dian 17.48 ng·g-1）. 31 isomers were detected in this study （PCB 8, 28, 30, 49, 52, 70, 74, 77, 82, 87, 99, 101, 105, 114, 118, 126, 128, 138, 153, 156, 158, 166, 169, 170, 179, 180, 183, 187, 189, 198 and 209, respectively）. Pentachloro- benzene, hexachlorobenzeneand heptachlorwere the major PCBs exposure and PCB 138 （4.73%）, 179 （4.15%）, 153 （3.92%）, 183 （3.89%）, 166 （3.77%）, 187 （3.74%） and 180 （3.67%）were the main components. Comparing to the United States, Spain, and Canada, respectively, PCBs exposure levels of Guangzhou pregnant women were extreme- ly high. Statistical results showed that age and BMI were positively related to PCBs exposure significantly. Statisti- cal results were more relevant whenpregnant women lived in the industrial areas than non-industrial areas.

关 键 词：多氯联苯(PCBs) 羊水 暴露水平 孕妇 广州 

分 类 号：X171.5[环境科学与工程—环境科学]