吸烟对术前TPF诱导化疗的口腔鳞癌患者术后切口愈合的影响研究  

THE INFLUENCE OF SMOKING AND PREOPERATIVE TPF INDUCED CHEMOTHERAPY ON WOUND HEALING OF ORAL SQUAMOUS CARCINMA PATIENTS AFTER SURGERY

作　　者：江献芳[1] 周诺[1] 蒙宁[1] 黄旋平[1] 巫家晓[1] 王代友[1] 吴训[1] 

机构地区：[1]广西医科大学附属口腔医院口腔颌面外科,南宁530021

出　　处：《广西医科大学学报》2015年第3期375-377,共3页Journal of Guangxi Medical University

基　　金：广西科技攻关课题资助项目(No.桂科攻0993003C-16);广西壮族自治区教育厅课题资助项目(No.200510023);广西医疗卫生重点科研课题资助项目(No.重200879)

摘　　要：目的:探讨吸烟对术前TPF诱导化疗的口腔鳞癌患者术后切口愈合的影响。方法:选择21例接受术前TPF诱导化疗的口腔鳞癌患者作为研究对象,根据患者吸烟与否分为吸烟组和非吸烟组,观察术后14d内切口缩小率、切口炎性反应及渗出量、术后VAS疼痛评分情况。结果:术后7,14d,吸烟组术后切口愈合速度比非吸烟组慢(P<0.05),而切口炎性反应重(P<0.05),切口渗出量多(P<0.05),术后VAS疼痛评分大于非吸烟组(P<0.05)。结论:吸烟对术前TPF诱导化疗的口腔鳞癌患者术后切口的愈合速度有影响。Objective. To analyze the effects of smokingand preoperative TPF induced chemotherapy on the wound healing of oral squamous carcinoma patients treated with operation. Methods. Twenty-one oral squamous carcinoma patients treated with TPF induced chemotherapy before surgery were enrolled into this study and divided into smoking group and non-smoking group. When patients were received operation after 14 days, their wound area reduced rate, inflammatory reaction, efflusion amount, pain analysis respectively were evaluated. Results： In the 7^th day and 14^th day after operation, the speed of wound healing , inflammatory reaction, efflusion amount and the pain sore in no smoking group were better than that in smoking group （ P 〈0. 05）. Conclusion： Smoking can reduce wound healing rate in oral squamous carcinoma pa-tients treated with TPF induced chemotherapy before surgery.

关 键 词：吸烟 TPF 诱导化疗 切口愈合 

分 类 号：R782[医药卫生—口腔医学]