白介素-27在多发性骨髓瘤中的表达及其临床意义  

EXPRESSION AND CLINICAL SIGNIFICANCE OF INTERLEUKIN-27 IN PATIENTS WITH MULTIPLE MYELOMA

作　　者：黄艳平[1] 黄锦雄[1] 韦夙[1] 韦敏[1] 杨飞燕[1] 刘琴[1] 王健琨[1] 

机构地区：[1]广西柳州市人民医院血液科,柳州545006

出　　处：《广西医科大学学报》2015年第3期388-390,共3页Journal of Guangxi Medical University

基　　金：广西壮族自治区卫生厅科研资助项目(N0.Z-2012578)

摘　　要：目的:探讨初治多发性骨髓瘤(MM)患者治疗前后白介素-27(IL-27)的水平及其临床意义。方法:选择对照组(健康体检者)40例,初治MM患者41例,采用ELISA法检测对照组及初治MM组治疗前后血清IL-27水平,并分析治疗前患者不同年龄、分型、血红蛋白、血肌酐、乳酸脱氢酶(LDH)、β2-微球蛋白(β2-MG)及D-S分期的血清IL-27水平。结果:血清IL-27水平在对照组为(18.32±6.70)ng/L,MM治疗前为(11.23±2.55)ng/L,治疗后有效组为(17.68±4.81)ng/L,治疗后无效组为(11.80±5.60)ng/L,治疗有效组较治疗前血清IL-27水平升高,差异有统计学意义(P<0.05),而治疗无效组较治疗前差异不明显(P>0.05)。治疗前血清IL-27水平在血红蛋白≥100g/L与<100g/L、LDH≥245U/L与<245U/L、β2-MG≥5.5mg/L与<5.5mg/L组间比较,差异均有统计学意义(均P<0.05)。而在年龄≥60岁与<60岁,血肌酐≥177μmol/L与<177μmol/L,D-S分期Ⅰ、Ⅱ、Ⅲ期及分型组间比较差异均无统计学意义(均P>0.05)。结论:MM患者血清IL-27水平下调,并与血红蛋白、LDH、β2-MG有关,提示其可能具有抗肿瘤作用。Objective： To explore the expression of interleukin-27（IL-27） and its clinical significance in multiple myeloma（MM）before and after treatment. Methods： 40 healthy people were chosen as control group and 41 cases MM with primary treatment were also enrolled in this study. Serumal level of IL-27 in the control group and MM group before and after treatment were detected by ELISA method. Meanwhile, analysing the correlation between IL-Z7 expression and the clinical characteristic of patients （including age, types,hemoglobin,creatinine,LDH,β2-microglobulin（β2-MG） and D-S stage）. Results： The level of IL-27 in MM group before treatment （11.23＋2.55） ng/L was lower than that of control group（18.32＋6.70） ng/L. After treatment, the level of IL-27 in the effective group were （17.68＋4.81） ng/L and it was significantly higher than the ineffective group（11. 80＋5.60） ng/L （ P 〈0.05）, and there not different between the invalid group and primary treatment group（ P 〉0.05）. Furthermore, the level of IL-27 in newly diagnosed patients with MM were significantly different between hemoglobin ≥100 g/L and〈100 g/L, LDH≥245 U/L and〈245 U/L, β2-MG≥5.5 mg/L and 〈5.5 mg/L,respectively（ P〈0. 05）. But there were not different between age ≥60 and〈60 years, creatinine≥177 μmol/L and〈177 μmol/L,neither during D-S stage Ⅰ , Ⅱ ,Ⅲand type IgG, IgA,no secretion,light chain（ P 〉0.05）. Conclusion：IL-27 dedines in MM,which has an anti-tumor effect and correlates with hemoglobin, LDH,β-MG.

关 键 词：白介素-27 多发性骨髓瘤 预后 LDH Β2-MG 

分 类 号：R733.3[医药卫生—肿瘤]