眼轴长度对非病理性近视黄斑区视网膜厚度的影响  

Effects of axial length on macular retinal thickness of non-pathological myopia

作　　者：宋爱萍[1] 于涛[1] 王建荣[1] 刘伟[1] 孙嬿[1] 

机构地区：[1]济南市第二人民医院眼科,山东省济南市250001

出　　处：《眼科新进展》2015年第8期754-758,共5页Recent Advances in Ophthalmology

基　　金：济南市卫生局科技计划项目资助(编号:2014-07)~~

摘　　要：目的 使用频域光学相干断层扫描（optical coherence tomography,OCT）研究眼轴长度对非病理性近视黄斑区视网膜厚度的影响。方法 筛选无眼底改变的近视患者90例90眼,男47例,女43例,年龄18~35岁。入选患者根据屈光度数和眼轴长度分为3组：低、中度近视组（low and medium myopia group,LMMG）,等效球镜度数为-0.50~〈-6.00 D且眼轴长度为24~〈26 mm,共29眼;高度近视组（high myopia group,HMG）,等效球镜度数为-6.00~〈-10.00 D且眼轴长度为26~〈28mm,共37眼;超高度近视组（super high myopia group,SHMG）,等效球镜度数≥-10.00 D且眼轴长度≥28 mm,共24眼。根据黄斑区9分区模式使用Cirrus HD-OCT检测入选患者黄斑区视网膜厚度和体积。使用单因素方差分析比较3组间黄斑区视网膜厚度测量值的差异。使用线性回归分析黄斑区视网膜厚度测量值与屈光度数和眼轴长度的关系。结果 HMG的内环下方黄斑厚度（inferior inner macular thickness,IIM）、内环颞侧黄斑厚度（temporal inner macular thickness,TIM）和外环所有象限的视网膜厚度测量值明显小于LMMG,但黄斑中心区厚度（central subfield thickness,CST）测量值明显大于LMMG（均为P〈0.05）。SHMG的IIM、TIM和外环所有象限的视网膜厚度测量值明显小于LMMG,但CST测量值明显大于LMMG（均为P〈0.05）。SHMG外环所有象限的视网膜厚度测量值明显小于HMG,但CST测量值明显大于HMG（均为P〈0.05）。CST测量值与屈光度数呈负相关,与眼轴长度呈正相关。内环平均厚度、IIM、TIM测量值与屈光度数呈正相关,与眼轴长度呈负相关。外环每一象限的厚度、外环平均厚度、黄斑区平均厚度和黄斑体积测量值与屈光度数均呈正相关,与眼轴长度均呈负相关。结论 随着眼轴长度和屈光度数的增加,非病理性近视眼黄斑中心视网膜厚度增加,内环和外环厚度降低。Objective To investigate the effects of axial length on macular reti- nal thickness of non-pathological myopia using spectral domain optical coherence tomo- graphy （OCT）. Methods A total of 90 eyes of 90 subjects （47 males and 43 females） who without other eye disorders except for myopia were included in the study. Subjects rang in age was from 18 years to 35 years. Subjects were divided into three groups ac- cording to their refractive error/ axial length： low and medium myopia group [ LMMG, spherical equivalent （SE） between - 0.50 D and - 6.00 D and axial length 24 - 25 mm, n = 29], high myopia group （ HMG, SE between - 6.00 D and - 10. 00 D and axial length 25 -28 mm,n = 37） and super high myopia group （ SHMG, SE≥ - 10.00 D and axial length≥ 28 mm, n = 34）. Cirrus HD-OCT was used to evaluate macular retinal thickness and macular volume. The differences among experimental groups were ana- lyzed by one-factor analysis of variance. Associations between macular thickness and refractive error/axial length were analyzed by Pearson correlation analysis. Results The inferior inner macular thickness （IIM） ,temporal inner macular thickness（TIM） and all quadrants of outer ring in HMG group were significantly less than those in LMMG group. However, the central subfield thickness （CST） in HMG group was significantly greater than that in LMMG group （ all P 〈 0.05 ）. IIM, TIM and all quadrants of outer ring in SHMG group were significantly less than those in LMMG group. However, the CST of SHMG group was significantly greater than that in LMMG group （ all P 〈 0.05 ）. Retinal thickness in all quadrants of outer ring in SHMG group was significantly less than those in HMG group. However,the CST in SHMG group was significantly greater than that of HMG （ all P 〈 0.05 ）. The CST had negative correlations with refractive error and positive correlations with axial length. The IIM,TIM, all the quadrants of outer ring, total average macular thickness and macular volume featured p

关 键 词：光学相干断层扫描 视网膜厚度 近视 眼轴长度 黄斑 

分 类 号：R774[医药卫生—眼科]