针刺左、右侧合谷穴脑功能偏侧性的fMRI研究  

Effects of acupuncture at left and right Hegu(LI 4)for cerebral function laterality

作　　者：汪林英 徐春生[2] 朱一芳[2] 李传富[2] 杨骏[1] 

机构地区：[1]安徽中医药大学第一附属医院针灸康复科,合肥230031 [2]安徽中医药大学第一附属医院影像中心,合肥230031

出　　处：《中国针灸》2015年第8期806-811,共6页Chinese Acupuncture & Moxibustion

基　　金：国家重点基础研究发展计划(973计划)项目:2010CB 530500;国家自然科学基金项目:81202768;安徽省教委重大科研项目:KJ 2011ZD 05;安徽省自然科学基金项目:1208085 MH 147;安徽中医药大学青年科学研究项目:2014qn030

摘　　要：目的:利用功能性磁共振成像(functional magnetic resonance imaging,fMRI)技术探讨针刺左、右侧合谷穴是否存在脑功能偏侧性,为临床合谷穴左、右侧选择提供客观依据。方法:将80名健康受试者随机分为针刺左侧合谷穴组(左侧针刺组)和针刺右侧合谷穴组(右侧针刺组),分别针刺左侧和右侧合谷穴。针刺得气后,采集两组的任务态fMRI数据,并利用功能性神经影像分析软件(analysis of functional neuroImages,AFNI)程序进行两组组内和组间分析。针刺后记录受试者的针刺感觉并统计两组针刺感觉量表(the MGH acupuncture sensation scale,MASS)指数。结果:两组间MASS指数比较差异无统计学意义(P>0.05);左侧针刺组主要表现为右侧大脑的信号增强,右侧针刺组显示双侧的大脑均有广泛信号变化;左侧针刺组与翻转后的右侧针刺组组间分析显示两组间存在差异脑区。结论:针刺左、右侧合谷穴的中枢效应不对称,存在右侧大脑半球的功能偏侧性;右侧大脑半球的岛叶和扣带回可能是针刺合谷穴发挥效应的关键脑区。Objective To explore the cerebral function laterality of acupuncture at left and right Hegu（LI 4）by using functional magnetic resonance imaging（fMRI）and provide objective evidences for side selection of Hegu（LI 4）in the clinical application.Methods Eighty healthy volunteers were randomly divided into a left-acupoint group and a right-acupoint group,and they were treated with acupuncture at left Hegu（LI 4）and right Hegu（LI4）respectively.After the arrival of qi,the task-state fMRI data in both groups was collected,and analysis of functional neuroimages（AFNI）software was used to perform intra-group and between-group comparisons.After acupuncture,acupuncture feelings were recorded and MGH acupuncture sensation scale（MASS）was recorded.Results The difference of MASS between the two groups was not significant（P〉0.05）.The result of left-acupoint group showed an increased signal on right cerebral hemisphere,while the right-acupoint group showed extensive signal changes in both cerebral hemispheres.The analysis between left-acupoint group and retroflex right-acupoint group showed differences in brain areas.Conclusions The central effect of acupuncture at left and right Hegu（LI 4）is dissymmetry,indicating right hemisphere laterality.The right lobus insularis and cingulate gyrus may be the key regions in the acupuncture at Hegu（LI 4）.

关 键 词：针刺 穴 合谷 偏侧性 功能性磁共振 

分 类 号：R224[医药卫生—中医基础理论]