肺癌^(18)F-FDG PET/CT最大标准摄取值的相关因素研究  

Study on relevant factors of maximum standard uptake value of ^(18)F-FDG PET/CT for lung cancer

作　　者：王少雁[1] 王辉[1] 左长京[2] 孙高峰[2] 陈素芸[1] 孔令山[2] 

机构地区：[1]上海交通大学医学院附属新华医院核医学科,上海200092 [2]第二军医大学附属长海医院核医学科,上海200433

出　　处：《上海交通大学学报（医学版）》2015年第7期1023-1027,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市科委基金(08411967800)~~

摘　　要：目的探讨肺癌18F-FDG PET/CT的最大标准摄取值(SUVmax)与肺癌临床病理学特征的关系。方法 82例经病理证实为肺癌的患者于治疗前行18F-FDG PET/CT检查。采用感兴趣区(ROI)勾画技术测量病灶SUVmax。采用SPSS 11.5统计软件对SUVmax与患者性别、年龄及肿瘤直径(最大径)、病理类型、临床分期及分化程度等因素的关系进行统计学分析。结果 82例肺癌患者中,腺癌52例,鳞癌23例,小细胞癌7例。不同病理类型病灶的SUVmax大小依次为鳞癌>小细胞癌>腺癌,其中腺癌与鳞癌SUVmax的差异有统计学意义(P<0.05);在肿瘤最大径<3 cm组中,不同病理类型肿瘤SUVmax的差异具有统计学意义(F=18.5,P<0.01);而在肿瘤最大径≥3 cm组中,不同病理类型肿瘤的SUVmax的差异无统计学意义(F=0.45,P=0.72)。Logistic多元线性回归分析结果显示:SUVmax与肿瘤最大径呈正相关,与肿瘤分化程度呈负相关;肿瘤直径和肿瘤分化程度对SUVmax存在多重共线性,校正直径因素后的回归模型显示分化程度为SUVmax的显著影响因素(β=0.618,t=7.52,P<0.05),而肿瘤分期及病理类型对SUVmax无显著影响。结论肺癌病灶的SUVmax与肿瘤最大径和分化程度相关,且对SUVmax具有多重共线性,在多因素分析时校正直径因素的条件下,肿瘤分化程度为SUVmax的显著影响因素,而肿瘤分期和病理类型对SUVmax无显著影响。Objective To investigate the relationship between maximum standard uptake value（SUV_（max）） and clinicopathological features of lung cancer with PET/CT scan.Methods A total of 82 patients with lung cancer who were confirmed by pathology underwent ^（18）F-FDG PET/CT before therapy.The SUV_（max） of the focus was measured and recorded by region of interest（ROI） technique.SPSS 11.5 was used to statistically analyze the relationship between SUV_（max） and clinical factors,including gender,age,diameter of tumor（maximum value）,pathological type,clinical staging,differentiation,etc.Results Among 82 cases of lung cancer,52 were adenocarcinoma,23 were squamous cell carcinoma,and 7 were small cell cancer.The descending order of SUV_（max） of different pathological types was that of squamous cell carcinoma,small cell carcinoma,and adenocarcinoma.The difference of SUV_（max） of squamous cell carcinoma and adenocarcinoma was statistically significant（P〈0.05）.Tumors were divided into≥3 cm group and 〈3 cm group.The differences of SUV_（max） of different pathological types of the 〈3 cm group were statistically significant（F = 18.5,P 0.01）.The differences of SUV_（max） of different pathological types of the ≥3 cm group were not statistically significant（F=0.45,P=0.72）.The results of multiple linear regression analysis showed the SUV_（max） positively correlated with the maximum diameter of tumor and negatively correlated with the differentiation of tumor.The differentiation and diameter of tumor were multicollinear with SUV_（max）.After the diameter factor was adjusted,the regression model showed that the differentiation of tumor was the significant influencing factor（β=0.618,t=7.52,P〈0.05）,while staging and pathological type did not significantly affect the SUV_（max）.Conclusion The SUV_（max） of lung cancer focus is relevant to the maximum diameter and differentiation of tumor,which are multicollinear with SUV_（max）.After the diameter factor has be

关 键 词：肺癌 计算机断层扫描术 正电子发射断层扫描 18F-氟脱氧葡萄糖 最大标准摄取值 

分 类 号：R734.2[医药卫生—肿瘤] R445[医药卫生—临床医学]