血管淋巴样增生伴嗜酸性粒细胞增多症临床病理观察  

A clinicopathological study of angiolymphoid hyperplasia with eosinophilia

作　　者：周炳娟[1] 张楠[2] 孙吉瑞 赵文明[1] 张金库[1] 

机构地区：[1]保定市第一中心医院病理科,河北保定071000 [2]保定市第一中心医院皮肤科,河北保定071000

出　　处：《临床与病理杂志》2015年第7期1318-1322,共5页Journal of Clinical and Pathological Research

摘　　要：目的:探讨血管淋巴样增生伴嗜酸性粒细胞增多症(angiolymphoid hyperplasia with eosinopilia,ALHE)的临床病理学特征、免疫组织化学染色(immunohistochemical stain,IHC)及鉴别诊断。方法:对3例ALHE进行临床病理分析及免疫组化研究,并进行文献复习。结果:2例ALHE为女性患者,1例为男性患者,病变位于头面部真皮内,组织形态以小到中等大小血管增生为主,血管内衬胞浆丰富的上皮样内皮细胞,血管周围见大量炎细胞浸润。免疫组化染色显示CD34、CD31、CD3阳性,CD20及CK阴性。结论:ALHE是一种少见的、良性的血管瘤,诊断主要依靠特征性组织学特点。Objective： To investigate the clinicopathologic features, immunophenotypes and differential diagnosis of angiolymphoid hyperplasia with eosinopilia （ALHE）. Methods： Three cases of ALHE were evaluated by the clinical and pathological characteristics and the immunohistochemical stain （IHC）. Results. In these cases, two patients were female and one was male. Histopathologically, they presented as a nodular lesion in the skin of head and neck region and the histopathological appearance of these cases were characterized by numerous thick and thin-walled vessels lined by characteristic epithelioid endothelial cells. Prominent inflammatory infiltrate including eosinophils, lymphocyte and plasma cells could be presented surrounding the vessels. Th immunohistochemistry revealed the positivity of these epithelioid endothelial cells for CD34, CD31 and CD3, the negative for CD20 and CK. Conclusion： ALHE is a rare benign vascular lesion and the diagnosis mainly depends on histopathological characteristics.

关 键 词：血管淋巴样增生伴嗜酸性粒细胞增多症 临床病理观察 

分 类 号：R732.2[医药卫生—肿瘤]