青光眼患者血清及房水一氧化氮浓度的测定及意义  

Detection of nitric oxide concentration in serum and aqueous humor of glaucoma patients

作　　者：申家泉[1] 楚艳华[2] 康汝秀[2] 岳爱环[2] 刘真[2] 李琳[2] 王荣[2] 

机构地区：[1]山东大学医学院眼科教研室,山东省立医院眼科 [2]山东省立医院眼科

出　　处：《山东大学学报（医学版）》2002年第4期352-353,共2页Journal of Shandong University:Health Sciences

摘　　要：目的 :测定青光眼患者血清及房水一氧化氮 (NO)浓度并探讨其在青光眼发病中的作用。方法 :应用硝酸还原酶法测定各型青光眼患者 (实验组 )及白内障患者 (对照组 )血清及房水NO浓度。结果 :两组患者血清NO浓度无统计学差异 (P >0 .0 5 ) ;实验组各青光眼类型之间血清NO浓度无差异 (P >0 .0 5 ) ;实验组房水NO浓度高于对照组(P <0 .0 1 ) ,原发性开角型青光眼房水NO浓度低于对照组及其它类型青光眼组 ,闭角型青光眼房水NO浓度较对照组显著升高 (P <0 .0 1 )。结论 :开角型青光眼由于房角原生型一氧化氮合成酶(NOS)的减少引起房水NO浓度的降低 ,导致房水外流阻力增大 ,眼压升高可引起闭角型青光眼患者房水NO浓度升高 。Objective:To measure the concentration of nitric oxide (NO) in serum and aqueous humor of the glaucoma patients and study its possible role in the pathogenesis of glaucoma. Methods:The NO concentration in serum and aqueous humor of glaucoma patients(test group) and cataract patients(control group) was detected by nitric acid reductase method. Results: No significant difference of NO concentration was found in serum between the two groups(P>0.05). The NO concentration in aqueous humor of primary open angle glaucona (POAG) was significantly lower than that of the control group(P<0.01) and the NO concentration of the angle closure glaucoma(ACG) was significantly higher than that of the control group(P<0.01). Conclusion: For POAG , the decrease of NO concentration in aqueous humor may be caused by the decrease of constitutive nitric oxide synthase(NOS) in anterior chamber angle, which can cause higher outflow resistance of aqueous humor, this may accout for one aspect of the pathogenesis of glaucoma. For ACG, the elevation of intraocular pressure can cause the increase of NO concentration in aqueous humor , and excessive NO can damage the trabecular meshwork,adjacent uvei and retina.

关 键 词：测定 青光眼 一氧化氮 血清 房水 

分 类 号：R775[医药卫生—眼科]