Increased risk of second malignancy in pancreatic intraductal papillary mucinous tumors: Review of the literature  

作　　者：Gian Luca Baiocchi Sarah Molfino Barbara Frittoli Graziella Pigozzi Federico Gheza Giacomo Gaverini Antonio Tarasconi Chiara Ricci Francesco Bertagna Luigi Grazioli Guido AM Tiberio Nazario Portolani 

机构地区：[1]Department of Medical and Surgical Sciences, Surgical Clinic, University of Brescia [2]1~(st) Department of Radiology,Brescia Civil Hospital [3]Department of Medical and Surgical Sciences, Gastroenterological Unit, University of Brescia [4]Department of Surgical Specialties,Radiological and Forensic Sciences, Nuclear Medicine Section,University of Brescia

出　　处：《World Journal of Gastroenterology》2015年第23期7313-7319,共7页世界胃肠病学杂志（英文版）

摘　　要：AIM: To analyze the available evidence about the risk of extrapancreatic malignancies and pancreatic ductal adenocarcinoma associated to pancreatic intraductal papillary mucinous tumors(IPMNs).METHODS: A systematic search of literature was undertaken using MEDLINE, EMBASE, Cochrane and Web-of-Science libraries. No limitations for year of publication were considered; preference was given to English papers. All references in selected articles were further screened for additional publications. Both clinical series and Literature reviews were selected. For all eligible studies, a standard data extraction form was filled in and the following data were extracted: study design, number of patients, prevalence of pancreatic cancer and extrapancreatic malignancies in IPMN patients and control groups, if available.RESULTS: A total of 805 abstracts were selected and read; 25 articles were considered pertinent and 17 were chosen for the present systematic review. Eleven monocentric series, 1 multicentric series, 1 casecontrol study, 1 population-based study and 3 case report were included. A total of 2881 patients were globally analyzed as study group, and the incidence of pancreatic cancer and/or extrapancreatic malignancies ranged from 5% to 52%, with a mean of 28.71%.When a control group was analyzed(6 papers), the same incidence was as low as 9.4%.CONCLUSION: The available Literature is unanimous in claiming IPMNs to be strongly associated with pancreatic and extrapancreatic malignancies. The consequences in IPMNs management are herein discussed.AIM: To analyze the available evidence about the risk of extrapancreatic malignancies and pancreatic ductal adenocarcinoma associated to pancreatic intraductal papillary mucinous tumors(IPMNs).METHODS: A systematic search of literature was undertaken using MEDLINE, EMBASE, Cochrane and Web-of-Science libraries. No limitations for year of publication were considered; preference was given to English papers. All references in selected articles were further screened for additional publications. Both clinical series and Literature reviews were selected. For all eligible studies, a standard data extraction form was filled in and the following data were extracted: study design, number of patients, prevalence of pancreatic cancer and extrapancreatic malignancies in IPMN patients and control groups, if available.RESULTS: A total of 805 abstracts were selected and read; 25 articles were considered pertinent and 17 were chosen for the present systematic review. Eleven monocentric series, 1 multicentric series, 1 casecontrol study, 1 population-based study and 3 case report were included. A total of 2881 patients were globally analyzed as study group, and the incidence of pancreatic cancer and/or extrapancreatic malignancies ranged from 5% to 52%, with a mean of 28.71%.When a control group was analyzed(6 papers), the same incidence was as low as 9.4%.CONCLUSION: The available Literature is unanimous in claiming IPMNs to be strongly associated with pancreatic and extrapancreatic malignancies. The consequences in IPMNs management are herein discussed.

关 键 词：INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM PANCREAS Diagnosis Follow-up Tumors COMPUTEDTOMOGRAPHY scan 18FDG-PET 

分 类 号：R735.9[医药卫生—肿瘤]