Seroepidemiology of hepatitis B virus infection and impact of vaccination  

作　　者：Peng Huang Li-Guo Zhu Ye-Fei Zhu Ming Yue Jing Su Feng-Cai Zhu Hai-Tao Yang Yun Zhang Hong-Bing Shen Rong-Bin Yu Xiang-Jun Zhai Zhi-Hang Peng 

机构地区：[1]Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University [2]Jiangsu Provincial Centre for Disease Control and Prevention [3]Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University [4]Department of Epidemiology, Medical Institute of Nanjing Army

出　　处：《World Journal of Gastroenterology》2015年第25期7842-7850,共9页世界胃肠病学杂志（英文版）

基　　金：Supported by National S and T Major Project Foundation of China,No.2011ZX10004-902;Priority Academic Program Development of Jiangsu Higher Education Institutions,Jiangsu Province Health Development Project with Science and Education,No.ZX201109;Research and Innovation Project for College Graduates of Jiangsu Province of China,No.KYZZ_0265

摘　　要：AIM: To investigate hepatitis B virus(HBV) prevalence in the general population in China.METHODS: A total of 148931 individuals were investigated by multistage random sampling in Eastern China. Data were collected on demographics and hepatitis B vaccination history, and serum was tested for hepatitis B surface antigen(HBs Ag) by ELISA. RESULTS: A total of 11469 participants(7.70%, 95%CI: 7.57%-7.84%) were positive for HBs Ag. HBs Ag prevalence was 0.77% among children < 5 years old but increased progressively from adolescents(1.40%-2.55%) to adults(5.69%-11.22%). A decrease in HBs Ag prevalence was strongly associated with vaccination and familial history of HBV among both children and adult groups. Meanwhile, HBs Ag risk in adults was associated with invasive testing and sharing needles. The HBV immunization rate among participants aged < 20 years was 93.30%(95%CI: 93.01%-93.58%). Significant difference in HBs Ag prevalence appeared between vaccinated and unvaccinated participants(3.59% vs 10.22%). CONCLUSION: Although the national goal of HBs Ag prevalence < 1% among children < 5 years old has been reached, immunization programs should be maintained to prevent resurgence.AIM: To investigate hepatitis B virus(HBV) prevalence in the general population in China.METHODS: A total of 148931 individuals were investigated by multistage random sampling in Eastern China. Data were collected on demographics and hepatitis B vaccination history, and serum was tested for hepatitis B surface antigen(HBs Ag) by ELISA. RESULTS: A total of 11469 participants(7.70%, 95%CI: 7.57%-7.84%) were positive for HBs Ag. HBs Ag prevalence was 0.77% among children < 5 years old but increased progressively from adolescents(1.40%-2.55%) to adults(5.69%-11.22%). A decrease in HBs Ag prevalence was strongly associated with vaccination and familial history of HBV among both children and adult groups. Meanwhile, HBs Ag risk in adults was associated with invasive testing and sharing needles. The HBV immunization rate among participants aged < 20 years was 93.30%(95%CI: 93.01%-93.58%). Significant difference in HBs Ag prevalence appeared between vaccinated and unvaccinated participants(3.59% vs 10.22%). CONCLUSION: Although the national goal of HBs Ag prevalence < 1% among children < 5 years old has been reached, immunization programs should be maintained to prevent resurgence.

关 键 词：EPIDEMIOLOGICAL study FAMILIAL history Hepatitis B surface ANTIGEN IMMUNIZATION Generalpopulation 

分 类 号：R512.62[医药卫生—内科学]