机构地区:[1]青岛大学医学院营养研究所,266021 [2]山东省临沂市人民医院东医疗区
出 处:《结核病与肺部健康杂志》2015年第2期89-92,共4页Journal of Tuberculosis and Lung Health
基 金:国家自然科学基金(81172662)
摘 要:目的 了解耐多药肺结核患者的营养状况,为促进其治疗和康复提供科学依据.方法 搜集2012-2014年间在临沂市人民医院住院治疗的109例耐多药肺结核患者,其中初治组(初治耐多药肺结核患者)58例,复治组(复治耐多药肺结核患者)51例.记录两组患者入院时体格检查和血液学检查结果,包括体质量指数(BMI):<18.5为营养不良(消瘦),18.5~23.9为正常,≥24为超重或肥胖;血红蛋白(Hb):<110 g/L为营养不良(贫血),110~150 g/L为正常;外周血淋巴细胞计数(TLC):<2.0×10^9/L为营养不良(TLC减少),(2~3.2)×10^9/L为正常;血清白蛋白(Alb):<35 g/L为营养不良(低蛋白血症),35~55 g/L为正常,按照以上指标检测结果分析比较患者的营养状况.结果 109例耐多药肺结核患者中,消瘦者占42.2%(46/109),贫血者占29.4%(32/109),TLC减少者占69.7%(76/109),低蛋白血症者占55.0%(60/109).其中初治组患者消瘦者占37.9%(22/58),贫血者占27.6%(16/58),TLC减少者占69.0%(40/58),低蛋白血症者占41.4%(24/58);复治组患者消瘦者占47.1%(24/51),贫血者占31.4%(16/51),TLC减少者占70.6%(36/51),低蛋白血症者占70.6%(36/51).初治组和复治组仅以白蛋白(ALB)评价的营养不良差异有统计学意义(x^2=9.356,P<0.05).两组各项营养指标检测结果:初治组患者的BMI、Hb、TLC、Alb水平分别为20.58、124.41 g/L、1.63×10^9/L、35.26 g/L;复治组患者分别为18.06、116.86 g/L、1.42×10^9/L、31.53 g/L,初治组患者各项指标差异均高于复治组(x2值分别为4.438、2.215、2.122、3.638,P值均<0.05).结论 耐多药肺结核患者营养不良的发生率较高,且复治组与初治组相比营养状况更差,在临床治疗过程中,应着重考虑患者的营养状况,尽早对患者采取具有针对性的营养支持治疗措施.Objective To study the nutritional status of the patients with multi-drug resistant pulmonary tuberculosis and provide scientific basis for promoting the treatment and rehabilitation. Methods Collected 109 cases of patients with multi-drug resistant pulmonary tuberculosis who were hospitalized in people's hospital of Linyi during the period of 2012 to 2014, including the initial treatment group (untreated patients with multi-drug resistant pulmonary tuberculosis) 58 cases, the retreatment group (the retreated patients with multi-drug resistant pulmonary tuberculosis) 51 cases. The two groups were collected at admission physical examination and blood test results, including body mass index (BMI) : 〈 18. 5 as malnutrition (thin), 18. 5 - 23.9 as normal, ≥24 as overweight or obese); hemoglobin (Hb (g/L): 〈110 as malnutrition (anemia), 110-150 as normal); external peripheral blood lymphocyte count (TLC (× 10^9/L) : 〈2. 0 ×10^9/L as malnutrition (TLC reduction), 2- 3. 2 as normal) ; serum albumin count (Alb (g/L) : 〈35 as malnutrition (hypoproteinemia), 35-55 as normal), according to above indicators results to analyze and compare the nutritional status of patients. Results Among 109 patients with multi-drug resistant pulmonary tuberculosis, low weight accounted for 42.2% (46/109), anemia accounted for 29.4% (32/109), TLC reduction accounted for 69.7% (76/109), low protein accounted for 55.0% (60/109). In initial treatment group patients, the low weight accounted for 37.9% (22/58), anemia accounted for 27.6% (16/58), TLC reduction accounted for 69.0% (40/58), low protein accounted for 41.4% (24/58) ; In the retreatment group, low weight accounted for 47.1% (24/51), anemia accounted for 31.4% (16/51), TLC reduction accounted for 70.6% (36/51), low protein accounted for 70. 6% (36/51), the initial treatment and retreatment group only to Albumin (Alb) evaluation of malnutrition had significant d
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