miRNAs对药物代谢酶的转录后调控  

Post-transcription regulation of drug metabolic enzymes by miRNAs

作　　者：王沛[1,2] 李晓天[1] 张莉蓉[2] 

机构地区：[1]郑州大学药学院药理学系,河南郑州450001 [2]郑州大学基础医学院药理学教研室,河南郑州450001

出　　处：《中国药理学通报》2015年第8期1037-1040,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81173127)

摘　　要：micro RNAs(mi RNAs)是一类小分子非编码RNAs,通过与靶基因互补配对在转录后水平调控基因表达。生理环境的改变(药物、致癌物、激素、压力或癌症等)会导致mi RNA表达的改变而影响药物代谢或药效的改变。对药物代谢酶相关的mi RNA进行评价可为个体化治疗提供有价值的信息。该文就mi RNA对Ⅰ相和Ⅱ相代谢酶的转录后调控作用进行综述。microRNAs （miRNAs） are a family of short non-cod- ing RNAs that regulate the expression of target genes by binding to complementary regions. The miRNAs expression is readily al- tered by drugs, carcinogens, hormones, stress or diseases, and that might lead to changes in the drug metabolism, pharmacoki- netics or potency. Moreover, the evaluation of drug metabolicenzyme-related miRNAs would provide useful information for per- sonalized medicine. This review describes the current knowledge on the post-transcription regulation of drug metabolic enzymes by miRNAs.

关 键 词：MIRNAS 代谢酶 CYP450 UGT GST 转录后调控 

分 类 号：R-05[医药卫生] R342.2