Smac的促凋亡机制及其在肺癌诊治中的作用  

The Mechanism of Apoptotic for Smac and Its Effect in Lung Cancer Diagnosis and Treatment

作　　者：袁籦玮 李欣[1] 王艳[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,黑龙江哈尔滨150086

出　　处：《中国肿瘤》2015年第8期677-681,共5页China Cancer

摘　　要：Smac/DIABLO作为线粒体蛋白中的一员可以调控细胞的凋亡。当存在凋亡信号刺激时,smac从线粒体重新定位入细胞质阻断了IAPs(抑制凋亡蛋白家族)与caspases的结合,恢复了caspases的活性。全文阐述了smac基因的结构、细胞定位和组织分布,概述其与IAP家族和另外一些凋亡蛋白之间的关联在促细胞凋亡中的作用,在肺癌的发生发展中的作用,以及在肺癌的诊断、治疗和预后判断中的意义。Smac as one kind of mitochondrial proteins,which also names DIABLO,is used for regulating apoptosis. Under stimulus of the apoptotic signals,smac is released from mitochondria to cytoplasm in order to restrain the binding activity between capases and IAPs（Inhibitor of Apoptosis Proteins）. This article reviews the structure characteristic,cellular localization and tissue distribution of smac,and accounts for its mechanism of boosting tumor cell apoptosis by demonstrating the link between smac and IAPs or other apoptosis regulatory factors,and the roles of smac in development and progression of lung cancer,and its relevance in lung cancer prognostic evaluation,diagnosis and treatment were reviewed in this article.

关 键 词：SMAC 细胞凋亡 肺癌 诊断 治疗 

分 类 号：R734.2[医药卫生—肿瘤]