老年人胃癌组织中原癌基因Yes相关蛋白异常表达及其与预后不良的相关性  

Abnormal expression of proto-oncogene YES-associated protein in gastric cancer tissues in the elderly and its correlation with the poor prognosis

作　　者：樊清波[1] 秦秉玉[1] 王存真[1] 刘晗[1] 刘卫青[1] 张慧峰[1] 程剑剑[1] 

机构地区：[1]河南省人民医院重症医学科,郑州450003

出　　处：《中华老年医学杂志》2015年第8期881-883,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨老年人胃癌组织中原癌基因Yes相关蛋白（YAP蛋白）表达异常表达及其和患者预后不良相关性。方法统计分析2011年3月至2014年10月我院收治的老年胃癌患者80例的临床资料。结果YAP蛋白在胃癌中的阳性表达率71．3％（57／80），显著高于癌旁组织13．8％（11／80）（P〈0．05）；YAP蛋白阳性表达率和胃癌肿瘤大小、肿瘤分期、浸润深度、淋巴结转移情况显著相关（P〈0．05），但和肿瘤分化无相关性（P〉0．05）；YAP蛋白阳性表达患者的5年生存率显著低于YAP蛋白阴性表达患者（P〈0．05），但两组患者的1年、3年生存率之间的差异无统计学意义（P〉0．05）；YAP蛋白表达、肿瘤分期、淋巴结转移和胃癌患者预后显著相关（P〈0．05）。结论老年人胃癌组织中YAP蛋白阳性表达率显著高于癌旁组织，YAP蛋白高表达率预示患者预后不良。Objective To investigate the abnormal expression of proto oncogene YES-associated protein （YAP） in gastric cancer tissues in the elderly and its correlation with poor prognosis. Methods Clinical data of 80 elderly patients with gastric cancer treated in our hospital from March 2011 to October 2014 were statistically analyzed Results The positive expression rate of YAP was significantly higher in gastric carcinoma than in adjacent tissues （71.3% （57/80） w 13.8%（11/ 80）, P〈0.05]. The positive expression of YAP were significantly associated gastric tumor size, tumor stage, invasion depth and lymph node metastasis （all P〈0.05）, but had no correlation with tumor differentiation （ P〉 0.05）. The 5-year survival rate was significantly lower in patients with YAP-positive expression than in patients with YAP-negative expression （P 〈 0.05）, but the differences in 1-year, 3-year survival rates were not significant between the two groups （all P〉0.05） The YAP expression, tumor stage, lymph node metastasis were significantly associated with the prognosis of gastric cancer in patients （all P〈20.05）. Conclusions YAP-positive expression rate is significantly higher in gastric cancer tissues than in adjacent tissues in the elderly, which indicates poor prognosis of patients with gastric cancer.

关 键 词：胃肿瘤 原癌基因蛋白质类 

分 类 号：R735.2[医药卫生—肿瘤]