神经降压素及其受体1(NTS/NTSR1)在肿瘤发生与发展中的作用及其机制  

Function and mechanism of neurotensin( NTS) and its receptor 1( NTSR1)in occurrence and development of tumors

作　　者：胡焕荣 董振[2] 易良[2] 何小燕[2] 张艳丽[1] 刘亚玲[1] 崔红娟[2] 

机构地区：[1]河北医科大学第三附属医院皮肤科,河北石家庄050000 [2]西南大学家蚕基因组生物学国家重点实验室,重庆400716

出　　处：《中国中药杂志》2015年第13期2524-2536,共13页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(31271462)

摘　　要：神经降压素(neurotensin,NTS)作为一种在中枢和外周神经系统广泛表达的神经肽,主要通过神经降压素受体1(neurotensin receptor1,NTSR1)的介导来激活下游信号通路。作者通过回顾近几年的研究结果,发现NTS/NTSR1在多种恶性肿瘤的发生发展中扮演着重要的角色。NTS/NTSR1主要通过诱导以IP3,Ca2+和PKC为中心的MAPKs级联活化通路,诱导以MMPs和EGFR为中心的MAPKs活化及PI3K/Akt通路的激活,或者调节Rho-GTPsaes和非受体酪氨酸激酶,从而调节肿瘤的发生、增殖、凋亡、转移及分化。除此之外,NTS/NTSR1还受到其他一些信号通路以及中药和中医疗法的调节。该文对NTS/NTSR1在多种肿瘤中的作用及其机制进行综述,并对其在临床诊断和药物靶向治疗上的应用进行展望。As a neuropeptide, neurotensin （NTS） is widely expressed in central and peripheral nervous system, which is mainly mediated byneurotensin receptorl （NTSR1） to activate the related downstream signaling pathways. After summarized the function and mechanism of NTS/NTSR1 in various malignant tumors, we found that NTS/NTSR1 played essential roles during tumor initiation and development. NTS/NTSR1 regulates tumor initiation, proliferation, apoptosis, metastasis and differentiation mainly through three path- ways, including IP3/Ca2＋/PKC/MAPKs pathway, MMPs/EGFR/MAPKs （PI3K/Akt） pathway, or Rho-GTPsaes and non-receptor tyrosine kinase pathway. Besides, NTS/NTSR1 is also regulated by some upstream pathways and some traditional Chinese medicine preparations and traditional Chinese medicine therapies. In this article, we summarized the function of NTS/NTSR1 and its mecha- nisms, and discussed the prospective in its application to clinical diagnosis and drugs targeting.

关 键 词：神经降压素 神经降压素受体1 恶性肿瘤 信号通路 诊断标志物 靶向治疗 

分 类 号：R730.2[医药卫生—肿瘤]