MicroRNA在酒精依赖机制中的作用  

Research of microRNAs on alcohol dependence

作　　者：辛凤[1] 刘丽萍[1] 胡建[1] 

机构地区：[1]哈尔滨医科大学附属第一医院精神科,哈尔滨市150001

出　　处：《中华行为医学与脑科学杂志》2015年第7期662-664,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81271471）;黑龙江省卫生厅科研课题（2012-519）

摘　　要：目的系统评价microRNA在酒精依赖发病机制中的作用。方法用计算机检索Medline，mirbase，PubMed，中文期刊全文数据库（CNKI），万方数据库和维普数据库，手工检索相关参考文献。文献检索时限均从建库至2014年7月。英文数据库以“Alcoholism,Alcohol Dependence,Alcohol Abstinence,Al-cohol Amnestic Disorder Fetal Alcohol Spectrum Disorders ,microRNA”等作为关键词检索；中文数据库以“酒中毒、酒依赖、胎儿酒精谱群障碍、酒精戒断、酒精性遗忘症、miRNA”等作为关键词检索。检索从建库至2014年7月的相关文献。结果最终纳入英文文献18条，中文文献8条。结论miRNA在酒精依赖的发生发展过程中发挥重要作用，异常表达的miRNAs的作用将成为下一步研究方向。miRNA可能成为酒精依赖诊断的新的生物学标记，还可能使得这一分子成为药靶，或是模拟这一分子进行新药研发，这将可能会给酒精依赖的治疗提供一种新的手段。Objective To evaluate the microRNA role in the pathogenesis of alcohol dependence. Meth- ods By computer retrieval Medline, mirbase, PubMed, Chinese journal full-text database （ CNKI ） , ten thousand database and VIP database, manual retrieval relevant references.Literature retrieval time limit are built from the li- brary until July 2014.English database to ＂Alcoholism, Alcohol Dependence, Alcohol Abstinence, Alcohol Amnestic Disorder Fetal Alcohol Spectrum Disorders,mirna＂ as keywords retrieval;Chinese database to ＂Alcoholism,Alcohol Dependence, Alcohol Abstinence,Alcohol Amnestic Disorder Fetal Alcohol Spectrum Disorders, microRNA, etc＂. Retrieved from the database to the related literature in July 2014. Results A total of 26 studies were recruited in- eluding 8 Chinese literatures and 18 English literatures. Conclusion Abnormal expression of miRNAs will be- come the next research direction.MicroRNAs may become new biomarker of alcohol dependence on diagnosis ,may also makes the molecular drug targets, or the molecular simulation for new drug research and development, this could be for the treatment of alcohol dependence provides a new means.

关 键 词：MICRORNA 酒依赖 酒精戒断 

分 类 号：R749.62[医药卫生—神经病学与精神病学]