心室颤动小鼠心肺复苏后情绪改变  

Mood Change in the Mice Experienced Ventricular Fibrillation and Cardiopulmonary Resuscitation

作　　者：李诺[1] 宋凤卿[1] 左艳芳[1] 陈蒙华[1] 

机构地区：[1]广西医科大学第一附属医院心血管病研究所,530021

出　　处：《岭南急诊医学杂志》2015年第3期173-174,177,共3页Lingnan Journal of Emergency Medicine

基　　金：国家自然科学基金(81460289;81201447);广西自然科学基金(2013GXNSFAA019189);广西高等学校立项科学项目(201204LX045)

摘　　要：目的:评估心室颤动小鼠心肺复苏后情绪变化。方法:14只雄性昆明小鼠随机进行分为复苏组和对照组,每组7只。复苏组小鼠进行诱导室颤(CA)/心肺复苏(CPR)实验,对照组小鼠不经历心脏骤停与心肺复苏。两组小鼠在复苏术前、术后1 d、2 d、3 d、7 d进行旷场试验,记录和比较两组小鼠在旷场试验箱的总行程、站立次数和中央区活动时间。结果:与对照组相比,复苏组小鼠在旷场试验中的总行程、站立次数和中央区时间在术后各时间点均显著下降(P<0.05)。结论:心室颤动小鼠在心肺复苏后出现抑郁和焦虑样情绪变化。Objective ：The purpose of this study was to assess the mood change of mice subjected to the ventricular fibrillation / cardiopulmonary resuscitation. Methods ：Fourteen Kunming male mice were randomly divided into two groups ： CA-gro（n=7） and Control-gro（n=7）. CA-gro were subject to CA / CP surgery,while the Control group were feed normally. Behavioral testing, including Total distance, Raring, Time of central zone of all animals, were assessed before surgery and at post-surgery Day 1,Day2, Day 3 and Day 7 via the Open-field test. Results ： Total distance, rearing and time of central zone in CA-gro showed a remarkable decrease after surgery comparing to the Controlgro（P〈0.05）. Conclusion ： The mice experienced CA / CPR show both depression-like and anxiety-like behavior.

关 键 词：心跳骤停 心肺复苏 行为 情绪 

分 类 号：R541.75[医药卫生—心血管疾病]