自体干细胞移植治疗缺血性脑卒中的临床疗效观察  

The clinical efficacy of antologous stem cell transplantation in the treatment of ischemic stroke

作　　者：吴灵芝[1] 成钢卫[1] 李水彬[1] 

机构地区：[1]中山大学附属梅州医院神经内二科,广东梅州514000

出　　处：《河南医学研究》2015年第6期27-28,共2页Henan Medical Research

基　　金：2014梅州市医药卫生科研立项课题目录(2014-B-31)

摘　　要：目的观察自体干细胞移植治疗缺血性脑卒中的临床疗效。方法选取86例缺血性脑卒中患者,随机分为常规治疗组与原位移植组,各43例。观察两组治疗过程中的不良反应,对两组发病10 d及3个月后的CT片进行ASPCTS评分及NIHSS评分。结果两组均无严重不良反应出现。治疗后观察组与对照组NIHSS评分均明显降低(P<0.05),ASPCTS评分明显升高(P<0.05);治疗后观察组NIHSS评分明显低于对照组(P<0.05),ASPCTS评分观察组明显高于对照组(P<0.05)。结论自体干细胞移植能减少脑梗死体积,促进神经功能恢复,对治疗缺血性脑卒中疗效显著。Objective To observe the clinical efficacy of antologous stem cell transplantation in the treatment of ischemic stroke. Methods 86 cases of ischemic stroke were randomly divided into conventional treatment group（ control group）and or-thotopic transplantation group（ observation group）,43 cases in each group. The adverse reactions during the treatment were ob-served and CT image on the 10 th day after onset and 3 months later were scored by the National Institutes of Health Stroke Scale （NIHSS）and the Alberta Stroke Program CT Score（ASPCTS）. Results No severe adverse reaction happened in both two groups. NIHSS scores was reduced and ASPCTS scores was elevated in both groups after treatment（P﹤0. 05）. NIHSS scores of observation group were lower and ASPCTS scores were higher than the control group（P﹤0. 05）. Conclusion antologous stem cell transplantation could decrease the infract size,improve the neurological function and had an good efficacy in the treatment of ischemic stoke.

关 键 词：脑卒中 粒细胞集落刺激因子 自体干细胞 原位移植 

分 类 号：R743.3[医药卫生—神经病学与精神病学]