体外循环引起血小板损伤的相关因素分析  

The Factors Affecting Platelet Function during Cardiopulmonary Bypass

作　　者：池昊育 刘志刚[2] 刘晓程[1,2] 

机构地区：[1]中国医学科学院北京协和医学院,北京100730 [2]泰达国际心血管病医院心外科,天津300457

出　　处：《医学综述》2015年第15期2775-2777,共3页Medical Recapitulate

摘　　要：体外循环是心内直视手术重要的辅助手段,非外科性出血是体外循环心内直视手术后的常见并发症,可危及患者生命。体外循环造成的血小板功能损伤被认为是体外循环心内直视手术后非外科性出血的主要原因。体外循环引起血小板损伤的因素主要包括低温、血液与气体接触、生物相容性、剪切力、鱼精蛋白、肝素、麻醉药物的使用、机血回输、血液稀释、体外循环流转时间等。Cardiopulmonary bypass（ CPB） is important to support the circulation during cardiac surgery . Postoperative nonsurgical bleeding of patients undergoing cardiac surgery with CPB is a common complica-tion,which sometimes endangers patient′s life.Platelet dysfunction is considered to be one of the main con-tributors to nonsurgical bleeding after CPB .Contributing factors to platelet dysfunction during CPB include hypothermia,blood-air interaction,biocompatibility,shear stress,protamine,heparin,anaesthetic,hemodilu-tion,duration of operation and shed blood retransfusion.

关 键 词：血小板损伤 体外循环 非外科性出血 

分 类 号：R54[医药卫生—心血管疾病]