国产长效亮丙瑞林应用于短方案控制性卵巢刺激的疗效观察  

Clinical effect of depot leuprorelin acetate used in short protocol of controlled ovarian stimulation for IVF cycle

作　　者：朱秀娴[1] 章晓乐[1,2] 傅永伦[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院,上海200011 [2]上海中医药大学附属曙光医院妇产科,上海201203

出　　处：《生殖医学杂志》2015年第8期612-617,共6页Journal of Reproductive Medicine

摘　　要：目的在冻融胚胎移植(FET)的前提下探讨国产长效亮丙瑞林应用于短方案进行控制性卵巢刺激(COS)的疗效。方法回顾性分析行体外受精/卵胞浆内单精子注射-冻融胚胎移植(IVF/ICSI-FET)患者资料共261例。共进行了261个COS周期,入组患者均采用短方案,根据COS过程中应用的促性腺激素释放激素激动剂(GnRH-a)的类型分为:A组,国产短效GnRH-a即曲普瑞林(182例);B组,国产长效GnRH-a即亮丙瑞林(贝依?,79例)。后续进行270个FET周期,其中A组226个周期,B组44个周期。统计分析两组的COS周期用药情况、IVF/ICSI-FET结局。结果A组的获卵数(8.54±5.64)与B组的获卵数(9.94±5.53)比较,无统计学差异(P>0.05);A组的HMG用量显著少于B组(1 485.99±575.29Uvs.1 783.86±462.44U,P<0.05);两组的临床妊娠率无统计学差异(50.88%vs.54.55%,P>0.05)。结论1.125mg国产长效亮丙瑞林(贝依?)能够用于短方案进行COS,简单有效,不影响其胚胎实验室结局及FET妊娠结局。Objective： To explore the effect domestic depot leuprorelin acetate in short protocol of controlled ovarian stimulation（COS）for IVF with subsequent frozen-thawed embryo transfer（FET）. Methods： A total of 261 IVF/ICSI patients undergoing COS in a short protocol were divided into two groups ： group A, short-acting gonadotropin releasing hormone agonist （GnRH-a）-triptorelin （ 182 cycles） group B,depot GnRH-a-domestic leuprorelin acetate（79 cycles）. After COS, 270 FET cycles had been performed. Results： The number of oocytes retrieved in group B was not significantly different from that in group A（9. 94±5.53 vs. 8.54±5.64,P〉0.05）. The HMG doses used in group B （1 783.86±462.44 U）were significantly higher that that in group A（1 485. 99±575.29 U）（P〈0.05）. The clinical pregnancy rate in group A （50.88%） was not significantly different from that in group B（54.55% ）（P〉0.05）. Conelusions： Domestic depot leuprorelin acetate（1. 125 mg）can be used in short protocol and obtain similar clinical outcome as short-acting GnRH-a.

关 键 词：长效促性腺激素释放激素激动剂 国产亮丙瑞林 短方案 控制性卵巢刺激 冻融胚胎移植 

分 类 号：R[医药卫生]