卒中后抑郁患者的认知功能与事件相关电位P300的研究  

Clinical study on congnitive function and event-related potential P300 in post-stroke depression

作　　者：赵红东[1] 唐冰[1] 王磊 陆敏[1] 陈霓红[1] 杨雪梅[1] 刘茜[1] 李峰林[1] 

机构地区：[1]南京医科大学附属南京医院神经内科,江苏210029 [2]盐城妇幼保健院设备科

出　　处：《脑与神经疾病杂志》2015年第4期280-282,共3页Journal of Brain and Nervous Diseases

基　　金：南京医科大学课题(重点项目09NJMUZ3)

摘　　要：目的探讨卒中后抑郁(PSD)患者认知功能及事件相关电位P300的特点。方法研究组为68例PSD患者,对照组为68例无卒中后抑郁的卒中患者。对所有的研究患者用简易精神状态量表(MMSE)评定认知功能及行P300检测,并进行对比分析。结果 PSD患者MMSE评分27.2±1.8较对照组评分25.8±1.3明显降低(P<0.05);PSD患者P300潜伏期381.3±26.8ms较对照组356.4±31.1ms明显延长(P<0.05);PSD患者经治疗HAMA评分降低,MMSE评分改善,P300潜伏期缩短。结论 PSD患者认知功能受损,P300潜伏期延长。P300潜伏期及波幅与MMSE评分及HAMA评分相关。Objective To approach the congnitive function and the event-related potential P300 characteristic feacture in post-stroke depression（PSD）.Methods 68 patients with PSD as experiment group and 68 patients with non-PSD were all measured with mimi-mental state examination （ MMSE） and P300 were recorded. Results MMSE scores in PSD were significant lower than contral group.The latent period of length P300 in PSD were significant longer than the controls.After treatment the scores of Hamilton anxiety Scale （HAMA）and atencies period of P300 in PSD were significantly improved.Conclusion The cognitive function in PSD are impaired .The lantent period length and amplitude are correcated with MMSE and HAMA.

关 键 词：卒中后抑郁 HAMA 评分 事件相关电位 P300 

分 类 号：R743.32[医药卫生—神经病学与精神病学]