兔肢体恶性软组织肿瘤术前大分割容积弧形调强放疗可行性研究  

Feasibility of preoperative hypo-fractionated volumetric modulated arc radiotherapy for malignant soft tissue tumor in rabbit extremity

作　　者：时广力 刘艳[2] 王崇文[1] 白靖平[1] 杨爱梅[2] 

机构地区：[1]新疆医科大学附属肿瘤医院骨与软组织科,乌鲁木齐830000 [2]新疆医科大学附属肿瘤医院磁共振科,乌鲁木齐830000

出　　处：《中华实用诊断与治疗杂志》2015年第8期763-766,共4页Journal of Chinese Practical Diagnosis and Therapy

基　　金：新疆维吾尔自治区研究生科研创新项目(XJGRI2014090)

摘　　要：目的探讨应用兔肢体软组织肿瘤模型实施术前大分割容积弧形调强放疗(volumetric modulated arc radiotherapy,VMAT)的可行性。方法成功构建30只兔VX2软组织肿瘤模型,2周后随机分为VMAT大分割放疗组10只(VMAT组)、常规分割调强放疗(intensity modulation radiated therapy,IMRT)放疗组10只(IMRT组)和对照组10只,给予的单次剂量分别为3Gy、2Gy和不采取任何处理。放疗结束后,3组行MRI扫描评估,并采用Envision法检测肿瘤组织Ki-67表达率。结果 VMAT组和IMRT组肿瘤体积[(21.11±2.36)、(23.56±3.21)cm3]和肿瘤组织Ki-67表达率[(49.67±2.34)%、(51.00±2.39)%]均小于对照组[(46.78±3.38)cm3,(68.22±5.21)%](P<0.01),VMAT组与IMRT组比较差异无统计学意义(P>0.05)。结论大分割VMAT在兔肢体恶性软组织肿瘤的术前放疗中可取得与常规分割IMRT相同疗效。Objective To investigate the feasibility of preoperative hypo-fractionated volumetric modulated arc radiotherapy （VMAT） for soft tissue tumor model in rabbit extremity. Methods Two weeks after the establishment of VX2 soft tissue tumor models, 30 rabbits were randomly divided into VMAT group receiving hypo-fractionated VMAT, IMRT group receiving conventionally fractionated intensity modulation radiated therapy, and control group, with 10 rabbits in each group, at the dose of 3, 2 and 0 Gy respectively. MR scanning was performed at the end of radiotherapy, and the expressions of Ki-67 were detected by Envision after radiation. Results The tumor volumes were （21.11 ± 2.36） cm3 and （23.56±3.21） cm3 , the expression rates of Ki-67 were （49.67±2.34）% and （51.00±2.39）% in VMAT and IMRT groups, significantly lower than those in control group （（46.78±3.38） cm3 , （68. 22±5.21）%） （P〈0.01）, and there were no significant differences between VMAT and IMRT groups （P〉 0.05）. Conclusion Preoperative hypo- fractionated VMAT can achieve the same therapeutic outcome for malignant soft tissue tumors in rabbit extremity as conventionally fractionated IMRT.

关 键 词：软组织肿瘤 容积调强弧形放疗 放射疗法 大分割放疗 

分 类 号：R738.6[医药卫生—肿瘤]