CNTF、LIF在腺样囊性癌的表达及临床意义  

作　　者：李雷激[1] 向兰[1] 覃纲[1] 祝琳[1] 张迪[1] 

机构地区：[1]泸州医学院附属医院耳鼻咽喉头颈外科,四川646000

出　　处：《当代医学》2015年第23期1-4,共4页Contemporary Medicine

摘　　要：目的检测睫状神经营养因子(ciliary neurotrophic factors,CNTF),白血病抑制因子(leukemia inhibitor factor,LIF)在腺样囊性癌(adenoid cystic carcinoma,ACC)组织中的表达,探讨CNTF、LIF在ACC发生发展及嗜神经侵袭(perineural invasion,PNI)转移等临床病理特征间的关系。方法采用免疫组化Envision法对CNTF、LIF在60例ACC组织及20例癌旁正常组织中的表达进行检测,结合患者临床病理资料,分析它们的表达与患者临床病理参数间的关系。结果 CNTF、LIF在癌旁正常组织中低表达,在ACC组织中呈高表达,CNTF在不同病理类型及T分期,是否有嗜神经侵袭、转移复发间差异有统计学意义(P<0.05),LIF在是否有嗜神经侵袭、转移复发间差异有统计学意义(P<0.05),CNTF、LIF在ACC中的表达呈显著正相关(P<0.05)。结论 CNTF、LIF与ACC的发生相关,并且与ACC的恶性进展关系密切,可作为判断ACC预后的生物学指标。Objective To detect the expression of Ciliary neurotrophic factors（CNTF）and leukemia inhibitor factor（LIF） in adenoid cystic carcinoma （ACC） tissues and normal tissues near the ACC, then investigate their relevance with oncogenesis and development of the ACC and with its clinical pathological features such as perineural invasion（PNI） and metastasis. Methods Immunohistochemistry Envision method was employed to detected the expression of CNTF and LIF in the 60 ACC tissues and 20 normal tissues near the ACC, Combined with patients＇ clinical information, the relationship between the CNTF and LIF expression and clinicopathological parameter was analyzed. Results CNTF and LIF were lower expressed in normal tissues while over expressed in ACC tissues.There were significant difference of CNTF expression in different pathological classification, T stage, and in the cases whether they had PNI, recurrence and metastasis or not, while there were significant difference of LIF expression in specimens whether in PNI, recurrence and metastasis or not .The expression of CNTF and LIF in the tissues of ACC was positive related. Conclusion CNTF and LIF expression are related with ACC oncogenesis and development, and they were closely associated with ACC＇ s malignant progress. We expect that they may provide effective biological evidence for diagnosing and treating ACC.

关 键 词：睫状神经营养因子 白血病抑制因子 腺样囊性癌 

分 类 号：R739.8[医药卫生—肿瘤]