IL-17基因rs763780位点多态性与胃癌患者预后的关联性研究  

A correlation study on rs763780 single nucleotide polymorphism of IL-17 gene and prognosis of gastric cancer patients

作　　者：孙志龙 单毓强[2] 陈健忠[1] 赵冲 

机构地区：[1]浙江省杭州市富阳区第二人民医院普外科,311404 [2]浙江省杭州市第一人民医院外科,310000

出　　处：《中华全科医学》2015年第10期1585-1587,1637,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2013KYB207)

摘　　要：目的 探讨IL-17基因rs763780位点多态性对胃癌患者预后的影响.方法 以462名胃癌患者作为研究对象,采用Taqman进行基因分型,用Kaplan-Meier方法、Log-rank检验和Cox回归分析IL-17基因rs763780多态性位点与胃癌患者预后的关联性.结果 与AA基因型患者相比,携带AG/GG基因型会显著降低胃癌患者的中位生存期（P＜0.001）.校正年龄、性别和其它临床病理资料后,与AA基因型相比,携带AG/GG基因型患者会增加65％的死亡风险（HR=1.65,95％CI：1.48～ 1.87,P＜0.001）.分层分析显示在肿瘤＞5 cm（HR=1.62,95％CI：1.24～1.79）、浸润深度为T3＋T4（HR =2.12,95％ CI：1.37 ～ 2.56）、有淋巴结转移（HR=2.27,95％ CI：1.65 ～2.63）、无远处转移（HR=1.26,95％CI：1.18 ～ 1.54）和TNMⅢ/Ⅳ分期（HR =2.24,95％CI：1.76 ～ 2.63）患者中,携带AG/GG患者与AA基因型患者相比死亡风险显著增高.进一步Cox回归分析显示IL-17基因rs763780位点是胃癌患者预后的独立危险因素.结论 IL-17基因rs763780位点多与胃癌预后有关,其为胃癌患者的预后判断和个性化治疗提供新的依据.Objective To investigate the association of the rs763780 single nucleotide polymorphism（SNP） of IL-17 gene with the prognosis of gastric cancer patients. Methods The rs763780 SNP in IL-17genewas genotyped among 462 gastric cancer patients using Taqman assays. The association between this SNP and the prognosis of patients with gastric cancer was investigated by Kaplain-Meier method ,log-rank test and Cox regression model. Results The patients with rs763780 AG/GG genotype have a shorter median survival time than those with AA genotype （P 〈 0.001 ）. The multivariate Cox re- gression model revealed that,compared with AA genotype,patients with AG/GG genotypes had a 65% increased death risk[ adjusted hazard ratio （HR） = 1.65,95% CI： 1.48 - 1.87, P 〈 0. 001 ]. Additionally, in the stratified analysis, rs763780 polymorphism was associated with significantly higher risk of death in the groups of tumor size 〉 5 cm, T3 ＋ T4 for depth of invasion, having lymph node metastasis, no distant metastasis, and lll/IV of TNM stage. Furthermore, Cox regression model result showed that rs763780 polymorphism was an independent prognostic factor for gastric cancer patients. Conclusion Rs763780 polymorphism of IL-17 gene was associated with the prognosis of the patients with gastric cancer. This SNP might be helpful for estimating the prognosis and designing individualized cancer treatment for gastric cancer patients.

关 键 词：胃癌 遗传变异 生存期 IL-17 

分 类 号：R735.2[医药卫生—肿瘤] R446.7[医药卫生—临床医学]