STAT3信号通路影响肿瘤放射敏感性的研究进展  

Research progress of signal transducer and activator of transcription 3 pathway on radiosensitivity of tumor

作　　者：王康[1] 白静[2] 

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014040 [2]包头市肿瘤医院放疗科,014030

出　　处：《临床肿瘤学杂志》2015年第7期658-661,共4页Chinese Clinical Oncology

摘　　要：信号转导与转录激活因子3(STAT3)在多数肿瘤中处于过表达状态,其与肿瘤增殖、分化及凋亡密切相关,该信号通路激活能促进肿瘤的生长及侵袭。新近研究发现STAT3异常活化可降低肿瘤的放射敏感性,促使肿瘤逃避射线的杀伤作用。肿瘤中STAT3的表达情况可用来评价放疗疗效和判断预后,抑制该通路能逆转肿瘤放疗耐受。对STAT3信号通路不断深入研究,可为肿瘤的靶向治疗提供更多新思路。Studies have shown that signal transducer and activator of transcription 3 （STAT3） is over-expressed in many ma- lignant tumors. This signal pathway is closely related to the proliferation, differentiation and apoptosis in tumor cells. The activation of the STAT3 pathway promotes tumor growth and invasion. Emerging studies demonstrated that the abnormal activation of STAT3 resulted in the decrease of tumor radiosensitivity and avoidance of being damaged by radiation. The expression of STAT3 in tumor can be used in evaluating curative effect and prediction of prognosis. Inhibition of STAT3 pathway can markedly reverse the radiotherapy tolerance. The continue research on STAT3 can provide us with more tumor targeting strategies.

关 键 词：信号转导与转录激活因子3 肿瘤 放射敏感性 

分 类 号：R730.51[医药卫生—肿瘤]