肺癌和肺结核患者血浆中D-二聚体检测的临床意义  

The clinical significance of plasma D-dimer in lung cancer and pulmonary tuberculosis

作　　者：孙勇[1] 丁湘彧[1] 张宝秋[1] 王雪玉[1] 勾秀丽[1] 张洁[1] 时广利[1] 

机构地区：[1]首都医科大学附属北京胸科医院检验科,北京101149

出　　处：《国际检验医学杂志》2015年第15期2129-2130,共2页International Journal of Laboratory Medicine

基　　金：国家863计划子课题基金资助项目(2011AA02A111)

摘　　要：目的：探讨肺癌和肺结核患者血浆中D‐二聚体水平及其临床意义。方法收集2014年7～10月首都医科大学附属北京胸科医院130例肺癌患者、126例肺结核患者和50例健康者血浆标本，应用全自动分析仪检测所有血浆标本中的D‐二聚体水平。结果肺癌患者血浆中D‐二聚体的水平显著高于健康者和肺结核患者（ Z＝2．704，P＜0．01）；肺结核患者血浆中D‐二聚体的水平显著高于健康者（Z＝2．54，P＜0．05）；血浆中D‐二聚体在晚期肺癌（Ⅲ期和Ⅳ期）患者中的表达水平显著高于Ⅰ期和Ⅱ期患者（Z＝2．195，P＜0．05）。血浆D‐二聚体在肺癌患者中的阳性率（61．2％）显著高于肺结核患者（41．3％）（χ2＝10．525， P＜0．01）。结论肺癌和肺结核患者存在着明显的凝血和纤溶激活状态，通过监测血浆D‐二聚体的水平，血浆D‐二聚体水平与肺癌临床分期密切相关。Objective To evaluate the plasma levels of D‐dimer in lung cancer and pulmonary tuberculosis （PTB） patients and their clinical significances .Methods The plasma of 130 patients with lung cancer ,126 patients with PTB and 50 healthy controls were collected .All the patients were enrolled in Beijing Affiliated to Chest Hospital Capital Medical University ,from July 2014 to October 2014 .Full‐automatic analyzer was used to examine the level of plasma D‐dimer .Results The levels of plasma D‐dimer in patients with lung cancer were significantly higher than patients with PTB and healthy controls （Z=2 .704 ,P〈0 .01）;The levels of plasma D‐dimer in patients with PTB were significantly higher than healthy controls （Z=2 .54 ,P〈0 .05）;The levels of plasma D‐dimer were significantly higher in stages Ⅲ and Ⅳ than stages Ⅰ and Ⅱ（Z=2 .195 ,P〈0 .05）;The positive rate in patients with lung cancer was significantly higher than patients with PTB （χ2 =10 .525 ,P〈0 .01） .Conclusion Activation of coagulation and fi‐brinolysis exist in lung cancer and PTB patients ,the level of plasma D‐dimer is related to the clinical stage of lung cancer .

关 键 词：D-二聚体 肺癌 肺结核 

分 类 号：R734.2[医药卫生—肿瘤] R521[医药卫生—临床医学]